Immunological profile of teeth with inflammatory periapical disease from chronic liver disease patients

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dc.creatorJulia Mourão Braga
dc.creatorMarcela Carvalho Espaladori
dc.creatorMaria Elisa de Souza e Silva
dc.creatorLuciana Carla Brito Neves
dc.creatorLeda Quercia Vieira
dc.creatorAntônio Paulino Ribeiro Sobrinho
dc.date.accessioned2022-09-24T17:24:41Z
dc.date.accessioned2025-09-09T00:17:37Z
dc.date.available2022-09-24T17:24:41Z
dc.date.issued2018-08-08
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/iej.12992
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/45444
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Aberto
dc.subjectRNA messenger
dc.subjectCytokines
dc.subjectInfections
dc.subjectDental pulp cavity
dc.subject.otherAngiogenic factors
dc.subject.otherCytokines
dc.subject.otherEndodontics
dc.subject.otherLiver transplant
dc.subject.otherPeriapical disease
dc.titleImmunological profile of teeth with inflammatory periapical disease from chronic liver disease patients
dc.typeArtigo de periódico
local.citation.epage157
local.citation.issue2
local.citation.spage149
local.citation.volume52
local.description.resumoAim To evaluate the mRNA expression levels of the cytokines interferon-γ, tumour necrosis factor-α, interleukin (IL)-1β, IL-10, IL-6, VEGF, and AGT and the chemokine CCL2/MCP-1 in periapical interstitial fluid associated with root canal infections before and after the reduction of the bacterial load using a cleaning procedure. Methodology The case group included 11 patients with chronic liver disease, and the control group included 11 healthy patients. Clinical samples were taken from teeth with pulp necrosis. After cleaning and drying the canal, three paper points were introduced into the root canal and passed through the root apex (2 mm) into the periapical tissues for 1 min. The samples were collected immediately after root canal cleaning and 7 days later to characterize those gene expression levels using real-time PCR. The data were subjected to the Shapiro–Wilk and the Wilcoxon tests. Results In the control group, significantly increased expression of the pro-inflammatory cytokines IFN-γ and TNF-α was observed in teeth with restrained bacterial loads (day 7) (P < 0.05). Similarly, increased TNF-α expression was found on day 7 in the liver group (P < 0.05). No differences were observed in the expression levels of the IL-1β, IL-10 and, IL-6, MCP-1/CCL-2 and VEGF between the first collection (day 0) and second collection (day 7), over time in either group. Conclusion Chronic liver disease patients exhibited sufficient immunologic ability showing relatively similar expression levels of cytokines, chemokines and angiogenic factors in periapical samples compared with the responses from no-chronic liver disease patients. The outcomes of this study suggest that liver impairment did not compromise the periapical immune response
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12992

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