Perfil hematológico e bioquímico plasmáticode camundongos após ingestão da planta Arrabidaea chica

Abstract

The plant Arrabidaea chica(Humb. & Bonpl.) B. Verl. (Bignoniaceae), known as pariri is a native plant of tropical forests and known for its widespread use in folk medicine. The objective of this study was to investigate the action of A. chicain increased hematological and biochemical parameters plasma of mice (n=24) Swiss (Mus musculus) through continuous use (ad libitum),for 45 days,of water extracts and ethanol the leaves of A. chica. At the end of the test, a clinical evaluation to assess physical condition and body weight ofthe mice,was made after the blood of animals were collected by cardiac puncture. The results showed the ethanol extract was more efficient than the aqueous extract, an increase (p<0.05) of 9.2% in the concentration of red blood cells, 36.1% in white blood cells concentration and 29.5% in the concentration of platelets. As for plasma biochemical profile, the mice showed an increase (p <0.05) of the enzymesalkaline phosphatase and aspartate transaminase indicating hepatotoxicity. A. Chica has potential for exploitation in the pharmaceutical industry, because of its herbal medicine against diseases that debilitate hematological parameters, particularly in regard to platelet deficiency.