Risk factors for acute kidney injury after liver transplantation in intensive care unit: a retrospective cohort study

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dc.creatorAna Paula Camargos de Figueirêdo Neves
dc.creatorCecilia Gómez Ravetti
dc.creatorVandack Nobre
dc.creatorAngélica Gomides dos Reis Gomes
dc.creatorPaula Frizera Vassallo
dc.creatorAna Cristina Simões e Silva
dc.creatorFrancisco Guilherme Cancela e Penna
dc.creatorFabrício de Lima Bastos
dc.creatorMateus Rocha Muniz
dc.creatorGuilherme Carvalho Rocha
dc.creatorAugusto Cesar Soares Dos Santos Júnior
dc.date.accessioned2023-12-06T19:29:12Z
dc.date.accessioned2025-09-08T23:30:32Z
dc.date.available2023-12-06T19:29:12Z
dc.date.issued2022-08-08
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1516-3180.2021.0641.r2.12112021
dc.identifier.issn1806-9460
dc.identifier.urihttps://hdl.handle.net/1843/61805
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofSao Paulo Medical Journal
dc.rightsAcesso Aberto
dc.subjectUnidades de Terapia Intensiva
dc.subjectFatores de risco
dc.subjectMortalidade
dc.subject.otherAcute renal injury
dc.subject.otherAcute kidney injury
dc.subject.otherLiver transplantation
dc.subject.otherClinical outcome
dc.subject.otherPostoperative
dc.subject.otherCritically ill patients
dc.titleRisk factors for acute kidney injury after liver transplantation in intensive care unit: a retrospective cohort study
dc.typeArtigo de periódico
local.citation.epage565
local.citation.issue4
local.citation.spage559
local.citation.volume140
local.description.resumoBACKGROUND: Acute kidney injury (AKI) is a frequent complication during the postoperative period following liver transplantation. Occurrence of AKI in intensive care unit (ICU) patients is associated with increased mortality and higher costs. OBJECTIVE: To evaluate occurrences of moderate or severe AKI among patients admitted to the ICU after liver transplantation and investigate characteristics associated with this complication. DESIGN AND SETTING: Single-center retrospective cohort study in a public hospital, Belo Horizonte, Brazil. METHODS: Forty-nine patients admitted to the ICU between January 2015 and April 2017 were included. AKI was defined from a modified Kidney Disease Improving Global Outcomes (KDIGO) score (i.e. based exclusively on serum creatinine levels). RESULTS: Eighteen patients (36.7%) developed AKI KDIGO 2 or 3; mostly KDIGO 3 (16 out of the 18 patients). Lactate level within the first six hours after ICU admission (odds ratio, OR: 1.3; 95% confidence interval, CI: 1.021-1.717; P = 0.034) and blood transfusion requirement within the first week following transplantation (OR: 8.4; 95% CI: 1.687-41.824; P = 0.009) were independently associated with development of AKI. Patients with AKI KDIGO 2 or 3 underwent more renal replacement therapy (72.2% versus 3.2%; P < 0.01), had longer hospital stay (20 days versus 15 days; P = 0.001), higher in-hospital mortality (44.4% versus 6.5%; P < 0.01) and higher mortality rate after one year (44.4% versus 9.7%; P = 0.01). CONCLUSION: Need for blood transfusion during ICU stay and hyperlactatemia within the first six postoperative hours after liver transplantation are independently associated with moderate or severe AKI. Developing AKI is apparently associated with poor outcomes.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/spmj/a/85gnScq7vnPT6cpY3PkXSYC/?lang=en

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