Removal of the active pharmaceutical substance entecavir from water via the fenton reaction or action by the cyanobacterium Microcystis novacekii

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dc.creatorCléssius Ribeiro de Souza
dc.creatorGabriel Souza-Silva
dc.creatorCarolina Paula de Souza Moreira
dc.creatorOlívia Maria S. R. Vasconcelos
dc.creatorKenia Pedrosa Nunes
dc.creatorCíntia Aparecida J. Pereira
dc.creatorMarcos Paulo Gomes Mol
dc.creatorMicheline Rosa Silveira
dc.date.accessioned2026-03-03T20:48:02Z
dc.date.issued2024-12-05
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.3390/toxics12120885
dc.identifier.issn2305-6304
dc.identifier.urihttps://hdl.handle.net/1843/1895
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofToxics
dc.rightsAcesso aberto
dc.rightsCC0 1.0 Universalen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectEntecavir
dc.subjectAntiviral
dc.subjectReação de Fenton
dc.subjectCianobactéria
dc.subjectBioacumulação
dc.subject.otherEntecavir
dc.subject.otherFenton-like reaction
dc.subject.otherDegradation
dc.subject.otherCyanobacteria
dc.subject.otherMicrocystis
dc.titleRemoval of the active pharmaceutical substance entecavir from water via the fenton reaction or action by the cyanobacterium Microcystis novacekii
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage1
local.citation.volume12
local.creator.Latteshttp://lattes.cnpq.br/9021361848451956
local.creator.Latteshttp://lattes.cnpq.br/1874133350146990
local.creator.Latteshttp://lattes.cnpq.br/0225421873245171
local.creator.Latteshttp://lattes.cnpq.br/7424783439261321
local.creator.Latteshttp://lattes.cnpq.br/0144496689713578
local.description.resumoEntecavir (ETV) is an antiviral used to treat chronic infection caused by the hepatitis B virus, which affects approximately 250 million people worldwide. In order to mitigate the impacts of ETV on the environment, including potential harm to human health, this study evaluated the use of the Fenton-like reaction, which uses iron complexed with ethylenediaminetetraacetic acid (EDTA) at neutral pH, and the microbiological action of Microcystis novacekii in removing ETV from the aqueous medium. Aqueous concentrations of 100 mg/L were subjected to Fenton-like degradation. Solutions ranging from 1.2 to 120 mg/L were used for biodegradation. The results evidenced consistent effectiveness in completely removing ETV by the Fenton-like reaction after 90 s. However, removal by the action of M. novacekii did not return convincing results. Although entecavir exposure did not affect cyanobacterial cell growth, a gradual reduction in drug content was observed starting on the fourth day of exposure, with maximum removal of 28.9% at the lowest exposure concentration (1.2 mg/L), without, however, showing a significant difference. Statistically significant differences in drug removal were identified only after 14 days of exposure and at specific concentrations. The ETV degradation process through the Fenton reaction was effective and promising for practical application. Removal through M. novacekii showed limited efficacy for practical application for its direct use in the remediation of ETV in aquatic environments. However, we identified a slight decrease in the initial concentrations that could achieve greater efficiency in the drug’s degradation through associations with other microorganisms, physiochemical processes, or even genetic engineering.
local.identifier.orcidhttps://orcid.org/0000-0003-0884-1202
local.identifier.orcidhttps://orcid.org/0000-0002-3740-4346
local.identifier.orcidhttps://orcid.org/0000-0002-4838-7617
local.identifier.orcidhttps://orcid.org/0000-0002-2568-3579
local.identifier.orcidhttps://orcid.org/0000-0001-7002-4428
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.initialsUFMG
local.subject.cnpqCIENCIAS DA SAUDE
local.subject.cnpqCIENCIAS BIOLOGICAS
local.url.externahttps://www.mdpi.com/2305-6304/12/12/885

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