Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen

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dc.creatorLuara Isabela dos Santos
dc.creatorThais Abdala Torres
dc.creatorSuelen Queiroz Diniz
dc.creatorRicardo Gonçalves
dc.creatorGustavo Caballero-flores
dc.creatorGabriel Núñez
dc.creatorRicardo Tostes Gazzinelli
dc.creatorKevin Joseph Maloy
dc.creatorLis Ribeiro do v. Antonelli
dc.date.accessioned2023-09-14T19:11:43Z
dc.date.accessioned2025-09-09T00:59:14Z
dc.date.available2023-09-14T19:11:43Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2020.108613
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/1843/58678
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCell Reports
dc.rightsAcesso Aberto
dc.subjectMetabolismo
dc.subjectMalária
dc.subject.otherMetabolismo
dc.subject.otherMalária
dc.titleDisrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen
dc.typeArtigo de periódico
local.citation.epage18
local.citation.issue2
local.citation.spage108613
local.citation.volume34
local.description.resumoIndividuals with malaria exhibit increased morbidity and mortality when infected with Gram-negative (Gr−) bacteria. To explore this experimentally, we performed co-infection of mice with Plasmodium chabaudi and Citrobacter rodentium, an extracellular Gr− bacterial pathogen that infects the large intestine. While single infections are controlled effectively, co-infection results in enhanced virulence that is characterized by prolonged systemic bacterial persistence and high mortality. Mortality in co-infected mice is associated with disrupted iron metabolism, elevated levels of plasma heme, and increased mitochondrial reactive oxygen species (ROS) production by phagocytes. In addition, iron acquisition by the bacterium plays a key role in pathogenesis because co-infection with a mutant C. rodentium strain lacking a critical iron acquisition pathway does not cause mortality. These results indicate that disrupted iron metabolism may drive mortality during co-infection with C. rodentium and P. chabaudi by both altering host immune responses and facilitating bacterial persistence.
local.identifier.orcidhttps://orcid.org/0000-0002-1127-4483
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2211124720316028?via%3Dihub

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