Nanonization techniques to overcome poor water-solubility with drugs

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dc.creatorFlávia Lidiane Oliveira da Silva
dc.creatorMaria Betânia de Freitas Marques
dc.creatorKelly Cristina Kato
dc.creatorGuilherme Carneiro
dc.date.accessioned2022-05-24T22:20:40Z
dc.date.accessioned2025-09-08T23:52:54Z
dc.date.available2022-05-24T22:20:40Z
dc.date.issued2020
dc.identifier.doi10.1080/17460441.2020.1750591
dc.identifier.issn1746-0441
dc.identifier.urihttps://hdl.handle.net/1843/41944
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofExpert Opinion on Drug Discovery
dc.rightsAcesso Restrito
dc.subjectNanotecnologia
dc.subjectBiodisponibilidade
dc.subjectSistemas de entrega de drogas
dc.subject.otherBioavailability
dc.subject.otherBiopharmaceutical classification system
dc.subject.otherDissolution rate
dc.subject.otherDrug delivery systems
dc.subject.otherNanoparticles
dc.subject.otherSelf-emulsifying formulations
dc.subject.otherSolubility enhancement
dc.titleNanonization techniques to overcome poor water-solubility with drugs
dc.typeArtigo de periódico
local.citation.epage864
local.citation.issue7
local.citation.spage853
local.citation.volume15
local.description.resumoIntroduction: Most drugs used in therapy have low water-solubility, a factor that could reduce their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical development. Nanonization of drugs is the reduction of particles to nanoscale, increasing the surface area and consequently the saturation solubility and dissolution rate and resulting in higher bioavailability. Areas covered: This review provides an overview of the consequences of the poor water-solubility and the main strategies applied to increase the solubility of poorly water-soluble drugs. The relationship between the biopharmaceutical classification system and the solubilization process of the drug is also considered. Finally, it includes how drug nanoparticles and nanocarriers, especially lipid-based nanosystems, can overcome these challenges and which of these approaches are already available on the market. Expert opinion: Due to the growing importance of nanomedicines, especially for applications in poorly water-soluble drugs, it is important to clearly establish the specifications and quality criteria for nanonized drugs to ensure the quality and safety of nanoparticles.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.initialsUFMG
local.url.externahttps://www.tandfonline.com/doi/full/10.1080/17460441.2020.1750591

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