Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders

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dc.creatorJames Varni
dc.creatorRobert Shulman
dc.creatorMariella Self
dc.creatorSamuel Nurko
dc.creatorMiguel Saps
dc.creatorShehzad Saeed
dc.creatorAshish Patel
dc.creatorChelsea Vaughan Dark
dc.creatorCristiane Baccin Bendo Neves
dc.creatorJohn Pohl
dc.date.accessioned2024-05-10T18:37:21Z
dc.date.accessioned2025-09-09T00:17:08Z
dc.date.available2024-05-10T18:37:21Z
dc.date.issued2017-04
dc.identifier.doihttps://doi.org/10.1007/s11136-016-1430-3
dc.identifier.issn1573-2649
dc.identifier.urihttps://hdl.handle.net/1843/68188
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuality of Life Research
dc.rightsAcesso Restrito
dc.subjectIrritable bowel syndrome
dc.subjectConstipation
dc.subjectAbdominal pain
dc.subjectLocal symptoms
dc.subjectPatient reported outcome measures
dc.subjectIndicators of quality of life
dc.subject.otherIrritable bowel syndrome
dc.subject.otherFunctional constipation
dc.subject.otherFunctional abdominal pain
dc.subject.otherGastrointestinal symptoms
dc.subject.otherPatient-reported outcomes
dc.subject.otherPedsQL
dc.titleGastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders
dc.typeArtigo de periódico
local.citation.epage1025
local.citation.issue4
local.citation.spage1015
local.citation.volume26
local.description.resumoObjectives: To investigate the patient-reported multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with functional gastrointestinal disorders (FGIDs). Methods: The Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms Scales and PedsQL™ 4.0 Generic Core Scales were completed in a 9-site study by 259 pediatric patients with functional constipation, functional abdominal pain (FAP), or irritable bowel syndrome (IBS). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL. Results: Gastrointestinal symptoms were differentially associated with decreased HRQOL in bivariate analyses for the three FGIDs. In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms differentially accounted for an additional 47, 40, and 60 % of the variance in patient-reported HRQOL for functional constipation, FAP, and IBS, respectively, reflecting large effect sizes. Significant individual gastrointestinal symptoms predictors were identified after controlling for the other gastrointestinal symptoms in the FGID-specific predictive models. Conclusions: Gastrointestinal symptoms represent potentially modifiable predictors of generic HRQOL in pediatric patients with FGIDs. Identifying the condition-specific gastrointestinal symptoms that are the most important predictors from the patient perspective facilitates a patient-centered approach to targeted interventions designed to ameliorate impaired overall HRQOL.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11136-016-1430-3

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