Leiomyoma and leiomyosarcoma (primary and metastatic) of the oral and maxillofacial region: a clinicopathological and immunohistochemical study of 27 cases

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dc.creatorGabriela Ribeiro de Araújo
dc.creatorPablo Agustin Vargas
dc.creatorCinthia Verônica Bardalez Lopez de Cáceres
dc.creatorAlan Roger Santos-Silva
dc.creatorAna Carolina Prado Ribeiro
dc.creatorThaís Bianca Brandão
dc.creatorRamiro Alejandro Tomasi
dc.creatorRuth Salomé Ferreyra
dc.creatorOslei Paes de Almeida
dc.creatorFelipe Paiva Fonseca
dc.creatorSara Ferreira dos Santos Costa
dc.creatorRicardo Alves Mesquita
dc.creatorRicardo Santiago Gomez
dc.creatorJean Nunes dos Santos
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorBruno Augusto Benevenuto de Andrade
dc.creatorMário José Romañach
dc.creatorMichelle Agostini
dc.date.accessioned2023-12-07T20:48:59Z
dc.date.accessioned2025-09-09T00:20:58Z
dc.date.available2023-12-07T20:48:59Z
dc.date.issued2021-06-09
dc.identifier.doihttps://doi.org/10.1007/s12105-021-01336-2
dc.identifier.issn19360568
dc.identifier.urihttps://hdl.handle.net/1843/61839
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and neck pathology
dc.rightsAcesso Restrito
dc.subjectMandible
dc.subjectLeiomyoma
dc.subjectLeiomyosarcoma
dc.subjectMouth
dc.subjectSmooth muscle tumor
dc.subjectDiagnosis
dc.subjectNeoplasms
dc.subjectImmunohistochemistry
dc.subject.otherneoplasias de cabeça e pescoço
dc.subject.otherneoplasias de boca título periódico : busca dia 10 do 11 2023Head and neck pathology
dc.subject.otherneoplasias mesenquimais
dc.subject.otherfao clinica acesso restrito data busca 10 do 11 2023assunto Angiomyoma Leiomyoma and leiomyosarcoma (primary and metastatic) of the oral and maxillofacial region: a clinicopathological and immunohistochemical study of 27 cases
dc.titleLeiomyoma and leiomyosarcoma (primary and metastatic) of the oral and maxillofacial region: a clinicopathological and immunohistochemical study of 27 cases
dc.typeArtigo de periódico
local.citation.epage303
local.citation.issue1
local.citation.spage294
local.citation.volume16
local.description.resumoSmooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients' pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for α-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-021-01336-2

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