Impact of DMPEI on biofilm adhesion on latex urinary catheter

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dc.creatorVinícius Souza Tarabal
dc.creatorFlávia Gontijo da Silva
dc.creatorRubén Dario Sinisterra Millán
dc.creatorDaniel Bonoto Gonçalves
dc.creatorJosé Antonio Silva
dc.creatorJose Mauro Granjeiro
dc.creatorMarcelo Gomes Speziali
dc.creatorPaulo Afonso Granjeiro
dc.date.accessioned2023-11-27T19:58:09Z
dc.date.accessioned2025-09-08T23:49:13Z
dc.date.available2023-11-27T19:58:09Z
dc.date.issued2021
dc.identifier.doihttp://dx.doi.org/10.2174/1872208315666210215084127
dc.identifier.issn2212-4012
dc.identifier.urihttps://hdl.handle.net/1843/61417
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRecent Patents on Biotechnology
dc.rightsAcesso Restrito
dc.subjectBiofilme
dc.subjectCateteres
dc.subjectLatex
dc.subjectBiotecnologia microbiana
dc.subjectInfecções urinárias
dc.subjectAgentes antiinfecciosos
dc.subject.otherCatheter-associated urinary tract infection
dc.subject.otherDMPEI
dc.subject.otherBiofilm
dc.subject.otherUrinary catheter
dc.subject.otherLatex
dc.titleImpact of DMPEI on biofilm adhesion on latex urinary catheter
dc.typeArtigo de periódico
local.citation.epage66
local.citation.issue1
local.citation.spage54
local.citation.volume15
local.description.resumoBackground: Microorganisms can migrate from the external environment to the patient’s organism through the insertion of catheters. Despite being indispensable medical device, the catheter surface can be colonized by microorganisms and become a starting point for biofilm formation. Therefore, new technologies are being developed in order to modify surfaces to prevent the adhesion and survival of microorganisms. Patents with the use of DMPEI have been filed. Objective: In the present work, we coated latex catheter surfaces with 2 mg mL-1 DMPEI in different solvents, evaluated the wettability of the surface and the anti- biofilm activity of the coated catheter against Escherichia coli, Staphylococcus aureus, and Candida albicans. Methods: We coated the inner and outer catheter surfaces with 2 mg mL-1 of DMPEI solubilized in butanol, dimethylformamide, and cyclohexanone and the surfaces were analyzed visually. Contact angle measurement allowed the analysis of the wettability of the surfaces. The CFU mL-1 count evaluated E. coli, S. aureus, and C. albicans adhesion onto the control and treated surfaces. Results: The contact angle decreased from 50.48º to 46.93º on the inner surface and from 55.83º to 50.91º on the outer surface of latex catheters coated with DMPEI. The catheter coated with DMPEI showed anti-biofilm activity of 83%, 88%, and 93% on the inner surface and 100%, 92%, and 86% on the outer surface for E. coli, S. aureus, and C. albicans, respectively. Conclusion: Latex catheter coated with DMPEI efficiently impaired the biofilm formation both on the outer and inner surfaces, showing a potential antimicrobial activity along with a high anti-biofilm activity for medical devices.
local.identifier.orcidhttps://orcid.org/0000-0002-8736-8531
local.identifier.orcidhttps://orcid.org/0000-0002-7284-2026
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0002-8178-1026
local.identifier.orcidhttps://orcid.org/0000-0002-8027-8293
local.identifier.orcidhttps://orcid.org/0000-0003-3572-9670
local.identifier.orcidhttps://orcid.org/0000-0003-0322-0861
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/114184

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