Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice

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dc.creatorDiego dos Santos Ferreira
dc.creatorBruno Luís Jesus de Oliveira Pinto
dc.creatorVidhya Kumar
dc.creatorValbert Nascimento Cardoso
dc.creatorSimone Odília Fernandes
dc.creatorCristina Maria Souza
dc.creatorGeovanni Dantas Cassali
dc.creatorAnna Moore
dc.creatorDavid Edwin Sosnovik
dc.creatorChristian Taylor Farrar
dc.creatorElaine Amaral Leite
dc.creatorRicardo José Alves
dc.creatorMônica Cristina de Oliveira
dc.creatorAlexander Ramos Guimarães
dc.creatorPeter Caravan
dc.date.accessioned2022-05-06T21:40:37Z
dc.date.accessioned2025-09-08T23:43:39Z
dc.date.available2022-05-06T21:40:37Z
dc.date.issued2017-07
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.nano.2017.03.005
dc.identifier.issn1549-9634
dc.identifier.urihttps://hdl.handle.net/1843/41440
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNanomedicine: Nanotechnology, Biology and Medicine
dc.rightsAcesso Aberto
dc.subjectAtividade antitumoral
dc.subjectToxicidade cardíaca
dc.subjectModelo de tumor
dc.subjectMetástase óssea
dc.subjectCamundongos
dc.subject.otherHydroxyapatite-targeting
dc.subject.otherBisphosphonates
dc.subject.otherDoxorubicin
dc.subject.otherBone tumor
dc.subject.otherCardiotoxicity
dc.titleEvaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sensitive liposomal formulation in a bone metastasis tumor model in mice
dc.typeArtigo de periódico
local.citation.epage1701
local.citation.issue5
local.citation.spage1693
local.citation.volume13
local.description.resumoChemotherapy for bone tumors is a major challenge because of the inability of therapeutics to penetrate dense bone mineral. We hypothesize that a nanostructured formulation with high affinity for bone could deliver drug to the tumor while minimizing off-target toxicity. Here, we evaluated the efficacy and toxicity of a novel bone-targeted, pH-sensitive liposomal formulation containing doxorubicin in an animal model of bone metastasis. Biodistribution studies with the liposome showed good uptake in tumor, but low accumulation of doxorubicin in the heart. Mice treated with the bone-targeted liposome formulation showed a 70% reduction in tumor volume, compared to 35% reduction for free doxorubicin at the same dose. Both cardiac toxicity and overall mortality were significantly lower for animals treated with the bone-targeted liposomes compared to free drug. Bone-targeted, pH-sensitive, doxorubicin containing liposomes represent a promising approach to selectively delivering doxorubicin to bone tumors while minimizing cardiac toxicity.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483199/

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