The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines

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dc.creatorLuciana Lousada Ferreira
dc.creatorJoão Eduardo Gomes-Filho
dc.creatorFrancine Benetti
dc.creatorMarina Carminatti
dc.creatorEdilson Ervolino
dc.creatorAndré Luiz Fraga Briso
dc.creatorLuciano Tavarez Angelo Cintra
dc.date.accessioned2022-09-24T20:40:07Z
dc.date.accessioned2025-09-08T23:04:25Z
dc.date.available2022-09-24T20:40:07Z
dc.date.issued2017-08-30
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1111/iej.12852
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/45487
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Restrito
dc.subjectTooth bleaching
dc.subjectDiabetes Mellitus
dc.subjectTumor necrosis factors
dc.subjectCytokines
dc.subject.otherDental bleaching
dc.subject.otherDiabetes Mellitus
dc.subject.otherInflammatory response
dc.subject.otherProinflammatory cytokines
dc.titleThe effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines
dc.typeArtigo de periódico
local.citation.epage356
local.citation.issue03
local.citation.spage347
local.citation.volume51
local.description.resumoAim To evaluate the influence of tooth bleaching on immunoregulatory cytokines production (IL-6, Tumour necrosis factor (TNF)-α and IL-17) in the pulp tissue of normoglycaemic and diabetic rats. Methodology Twenty-eight rats were divided into normoglycaemic and diabetic rats (n = 14). Diabetes mellitus (DM) was induced with a single dose of alloxan diluted in citrate buffer via intramuscular injection. After DM confirmation, all rats were sedated and tooth bleaching was performed using 35% hydrogen peroxide on the right maxillary molars for 30 min. Left molars were used as controls. Bleaching resulted in four hemimaxillae groups: normoglycaemic (N), N-bleached (NBle), diabetic (D) and D-bleached (DBle). After 2 and 30 days, rats were euthanized and hemimaxillae processed for analysis by haematoxylin and eosin and immunohistochemistry. Results within and between animals were submitted to Wilcoxon signed-rank and Mann–Whitney tests (P < 0.05). Results At 2 days, the NBle group had mild, and the DBle had severe inflammatory infiltration in the pulpal tissue (P < 0.05). TNF-α and IL-6 cytokines were associated with increased immunolabelling in the bleached groups compared to nonbleached (P < 0.05). However, IL-17 had increased immunolabelling in the NBle compared to the N and DBle group (P < 0.05). At 30 days, reactionary dentine was observed in the coronal pulp of all bleached teeth and no inflammation was present (P > 0.05). TNF-α cytokines had increased immunolabelling in the DBle group compared to the D group (P < 0.05). However, for IL-6 and IL-17, no difference was observed in this period (P > 0.05). Conclusions Tooth bleaching increased IL-6 and TNF-α in the pulp tissue regardless of diabetes mellitus; however, diabetic rats had higher TNF-α levels for longer periods. Tooth bleaching influenced the increase in IL-17 in the early periods in normoglycaemic rats
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12852

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