Antitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4T1 mammary tumor growth in mice

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dc.creatorMarina Apocalypse Nogueira Pereira
dc.creatorEdiu Carlos da Silva Junior
dc.creatorIstefani Luciene Dayse da Silva
dc.creatorBárbara Andrade de Carvalho
dc.creatorEnio Ferreira
dc.creatorEric Francelino Andrade
dc.creatorLuiz Roberto Guimarães Guilherme
dc.creatorLuciano José Pereira
dc.date.accessioned2025-01-22T21:45:52Z
dc.date.accessioned2025-09-09T01:18:46Z
dc.date.available2025-01-22T21:45:52Z
dc.date.issued2023-01-12
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0278088
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1843/79419
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS ONE
dc.rightsAcesso Aberto
dc.subjectTumores
dc.subjectCarcinogênese
dc.subjectCastanha-do-brasil
dc.subjectNutrição e câncer
dc.subjectMamas - Câncer
dc.subjectCâncer
dc.titleAntitumor effect of selenium-rich Brazil nuts and selenomethionine dietary supplementation on pre-existing 4T1 mammary tumor growth in mice
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue1
local.citation.spage01
local.citation.volume18
local.description.resumoSelenium (Se) is an essential micronutrient known to play an important role in the antioxidant system that can potentially influence tumor growth. We aimed to investigate the effects of dietary Se supplementation after detection of 4T1 mammary tumor growth in BALB/c mice. Thirty female mice received subcutaneous inoculation of 4T1 cells. After five days, all animals presenting palpable tumors were randomly assigned to three groups: a control group (Se-control) receiving a diet with adequate Se (0.15 mg/kg) and two other groups that received Se-supplemented diets (1.4 mg/kg of total Se) with either Brazilian nuts (Se-Nuts) or selenomethionine (SeMet). Data were assessed by either One or Two-way ANOVA followed by Tukey’s HSD or Bonferroni’s post hoc tests, respectively. Both Se-supplemented diets reduced tumor volume from the thirteenth day of feeding compared with the Se-adequate (control) diet (p < 0.05). The SeMet group presented a higher Se blood concentration (p < 0.05) than the Se-control group, with the Se-Nuts group presenting intermediate values. Selenoprotein P gene expression in the liver was higher in the Se-Nuts group than in the Se-control group (p < 0.05), while the SeMet group presented intermediate expression. Dietary Se supplementation, starting after detection of 4T1 palpable lesions, reduced tumor volume in mice.
local.identifier.orcidhttps://orcid.org/0000-0003-2731-9532
local.identifier.orcidhttps://orcid.org/0000-0001-8592-2204
local.identifier.orcidhttps://orcid.org/0000-0003-0908-563X
local.identifier.orcidhttps://orcid.org/0000-0003-3870-3687
local.identifier.orcidhttps://orcid.org/0000-0002-1835-0303
local.identifier.orcidhttps://orcid.org/0000-0002-5387-6028
local.identifier.orcidhttps://orcid.org/0000-0002-0502-2554
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0278088

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