Toxicity of single-wall carbon nanotubes functionalized with polyethylene glycol in zebrafish (Danio rerio) embryos

Página do item simplificado
dc.creatorFelipe Antonio Girardi
dc.creatorDaniela Martí Barros
dc.creatorGisele Eva Bruch
dc.creatorCarolina da Silva Peixoto
dc.creatorLidiane Dal Bosco
dc.creatorSangram K. Sahoo
dc.creatorCarla Onara Ferreira Gonçalves
dc.creatorAdelina Pinheiro Santos
dc.creatorClascídia Aparecida Furtado
dc.creatorCristiano Fantini Leite
dc.date.accessioned2023-08-08T17:21:42Z
dc.date.accessioned2025-09-09T00:41:38Z
dc.date.available2023-08-08T17:21:42Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1002/jat.3346
dc.identifier.issn1099-1263
dc.identifier.urihttps://hdl.handle.net/1843/57612
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Applied Toxicology
dc.rightsAcesso Restrito
dc.subjectNanotubos de carbono
dc.subjectZebra danio
dc.subject.otherSingle-walled carbon nanotubes
dc.subject.otherEmbryotoxicity
dc.subject.otherZebrafish
dc.titleToxicity of single-wall carbon nanotubes functionalized with polyethylene glycol in zebrafish (Danio rerio) embryos
dc.typeArtigo de periódico
local.citation.epage221
local.citation.issue2
local.citation.spage214
local.citation.volume37
local.description.resumoSingle-wall carbon nanotubes functionalized with polyethylene glycol (SWCNT-PEG) are promising materials for biomedical applications such as diagnostic devices and controlled drug-release systems. However, several questions about their toxicological profile remain unanswered. Thus, the aim of this study was to investigate the action of SWCNT-PEG in Danio rerio zebrafish embryos at the molecular, physiological and morphological levels. The SWCNT used in this study were synthesized by the high-pressure carbon monoxide process, purified and then functionalized with distearoyl phosphatidylethanolamine block copolymer-PEG (molecular weight 2 kDa). The characterization process was carried out with low-resolution transmission electron microscopy, thermogravimetric analysis and Raman spectroscopy. Individual zebrafish embryos were exposed to the SWCNT-PEG. Toxic effects occurred only at the highest concentration tested (1 ppm) and included high mortality rates, delayed hatching and decreased total larval length. For all the concentrations tested, the alkaline comet assay revealed no genotoxicity, and Raman spectroscopy measurements on the histological slices revealed no intracellular nanotubes. The results shown here demonstrate that SWCNT-PEG has low toxicity in zebrafish embryos, but more studies are needed to understand what mechanisms are involved. However, the presence of residual metals is possibly among the primary mechanisms responsible for the toxic effects observed, because the purification process was not able to remove all metal contamination, as demonstrated by the thermogravimetric analysis. More attention must be given to the toxicity of these nanomaterials before they are used in biomedical applications.
local.identifier.orcidhttps://orcid.org/0000-0003-0436-7857
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.3346

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG