IMRT delivers lower radiation doses to dental structures than 3DRT in head and neck cancer patients

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dc.creatorEduardo Rodrigues Fregnani
dc.creatorThais Bianca Brandão
dc.creatorCláudia Joffily Parahyba
dc.creatorKarina Morais Faria
dc.creatorFelipe Paiva Fonseca
dc.creatorPedro Augusto Mendes Ramos
dc.creatorFábio Yone de Moraes
dc.creatorKarina Gondim Moutinho da Conceição Vasconcelos
dc.creatorGisela Menegussi
dc.creatorAlan Roger dos Santos Silva
dc.date.accessioned2023-08-07T18:17:08Z
dc.date.accessioned2025-09-09T01:29:19Z
dc.date.available2023-08-07T18:17:08Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.1186/s13014-016-0694-7
dc.identifier.issn1748-717X
dc.identifier.urihttps://hdl.handle.net/1843/57551
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRadiation Oncology
dc.rightsAcesso Aberto
dc.subjectRadioterapia
dc.subjectDentes
dc.subjectCabeça - Câncer
dc.subjectPescoço - Câncer
dc.subject.otherIntensity-modulated radiotherapy
dc.subject.other3D radiotherapy
dc.subject.otherHead and neck cancer
dc.subject.otherTeeth
dc.subject.otherDental structures
dc.titleIMRT delivers lower radiation doses to dental structures than 3DRT in head and neck cancer patients
dc.typeArtigo de periódico
local.citation.epage9
local.citation.issue116
local.citation.spage1
local.citation.volume11
local.description.resumoBackground Radiotherapy (RT) is frequently used in the treatment of head and neck cancer, but different side-effects are frequently reported, including a higher frequency of radiation-related caries, what may be consequence of direct radiation to dental tissue. The intensity-modulated radiotherapy (IMRT) was developed to improve tumor control and decrease patient’s morbidity by delivering radiation beams only to tumor shapes and sparing normal tissue. However, teeth are usually not included in IMRT plannings and the real efficacy of IMRT in the dental context has not been addressed. Therefore, the aim of this study is to assess whether IMRT delivers lower radiation doses to dental structures than conformal 3D radiotherapy (3DRT). Material and methods Radiation dose delivery to dental structures of 80 patients treated for head and neck cancers (oral cavity, tongue, nasopharynx and oropharynx) with IMRT (40 patients) and 3DRT (40 patients) were assessed by individually contouring tooth crowns on patients’ treatment plans. Clinicopathological data were retrieved from patients’ medical files. Results The average dose of radiation to teeth delivered by IMRT was significantly lower than with 3DRT (p = 0.007); however, only patients affected by nasopharynx and oral cavity cancers demonstrated significantly lower doses with IMRT (p = 0.012 and p = 0.011, respectively). Molars received more radiation with both 3DRT and IMRT, but the latter delivered significantly lower radiation in this group of teeth (p < 0.001), whereas no significant difference was found for the other dental groups. Maxillary teeth received lower doses than mandibular teeth, but only IMRT delivered significantly lower doses (p = 0.011 and p = 0.003). Ipsilateral teeth received higher doses than contralateral teeth with both techniques and IMRT delivered significantly lower radiation than 3DRT for contralateral dental structures (p < 0.001). Conclusion IMRT delivered lower radiation doses to teeth than 3DRT, but only for some groups of patients and teeth, suggesting that this decrease was more likely due to the protection of other high risk organs, and was not enough to remove teeth from the zone of high risk for radiogenic disturbance (>30Gy).
local.identifier.orcidhttps://orcid.org/0000-0001-5196-7631
local.identifier.orcidhttps://orcid.org/0000-0001-9128-3138
local.identifier.orcidhttps://orcid.org/0000-0002-4835-9624
local.identifier.orcidhttps://orcid.org/0000-0002-6657-4547
local.identifier.orcidhttps://orcid.org/0000-0001-9544-6555
local.identifier.orcidhttps://orcid.org/0000-0002-8410-4303
local.identifier.orcidhttps://orcid.org/0000-0003-2040-6617
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA SOCIAL E PREVENTIVA
local.publisher.initialsUFMG
local.url.externahttps://ro-journal.biomedcentral.com/articles/10.1186/s13014-016-0694-7#:~:text=Conclusion,radiogenic%20disturbance%20(%3E30Gy).

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