Oncogenic signalling pathways in benign odontogenic cysts and tumours

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dc.creatorMarina Gonçalves Diniz
dc.creatorCarolina Cavalieri Gomes
dc.creatorSílvia Ferreira de Sousa
dc.creatorGuilherme Machado Xavier
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-06-26T21:06:03Z
dc.date.accessioned2025-09-09T00:14:31Z
dc.date.available2025-06-26T21:06:03Z
dc.date.issued2017-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2017.07.021
dc.identifier.issn1879-0593
dc.identifier.urihttps://hdl.handle.net/1843/83189
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofOral Oncology
dc.rightsAcesso Restrito
dc.subjectGenetics
dc.subjectNeoplasms
dc.subjectOdontogenic cysts
dc.subjectOdontogenic tumors
dc.subjectMouth neoplasms
dc.subjectCarcinogenesis
dc.subjectSignal transduction
dc.subjectMutation
dc.subjectTherapeutics
dc.subject.otherBenign tumours
dc.subject.otherOdontogenic cysts
dc.subject.otherOdontogenic tumors
dc.subject.otherGenetics
dc.subject.otherOncogenic signalling
dc.subject.otherOncogenic mutations
dc.subject.otherOral cancer
dc.subject.otherTumorigenesis
dc.titleOncogenic signalling pathways in benign odontogenic cysts and tumours
dc.typeArtigo de periódico
local.citation.epage173
local.citation.spage165
local.citation.volume72
local.description.resumoThe first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin. Despite the presence of such alterations, the vast majority of odontogenic lesions are benign and never progress to the stage of malignant transformation. As these lesions are likely to develop due to developmental defects, it is possible that they harbour quiet genomes. Now the question arises - do they result from DNA replication errors? Specific candidate genes have been sequenced in odontogenic lesions, revealing recurrent BRAF mutation in the case of ameloblastoma, KRAS mutation in adenomatoid odontogenic tumours, PTCH1 mutation in odontogenic keratocysts, and CTNNB1 (Beta-catenin) mutation in calcifying odontogenic cysts. Studies on these benign and rare entities might reveal important information about the tumorigenic process and the mechanisms that hinder/halt neoplastic progression. This is because the role of relatively common oncogenic mutations seems to be context dependent. In this review, each mutation signature of the odontogenic lesion and the affected signalling pathways are discussed in the context of tooth development and tumorigenesis. Furthermore, behavioural differences between different types of odontogenic lesions are explored and discussed based on the molecular alteration described. This review also includes the employment of molecular results for guiding therapeutic approaches towards odontogenic lesions.
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-7820-4749
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837517302129?via%3Dihub

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