Molecular alterations in odontogenic keratocysts as potential therapeutic targets

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dc.creatorCarolina Cavalierigomes
dc.creatorLetícia Martins Guimarães
dc.creatorMarina Gonçalves Diniz
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-06-30T19:55:31Z
dc.date.accessioned2025-09-09T01:18:07Z
dc.date.available2025-06-30T19:55:31Z
dc.date.issued2017-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12591
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/83230
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectPatched-1 receptor
dc.subjectNeoplasms
dc.subjectOdontogenic tumors
dc.subjectTherapeutics
dc.subjectMutation
dc.subjectProteins
dc.subjectDNA methylation
dc.subjectRNA
dc.subjectOdontogenic cysts
dc.subjectHedgehog proteins
dc.subjectApoptosis
dc.subject.otherHh pathway inhibitors
dc.subject.otherPTCH1
dc.subject.otherBenign tumors
dc.subject.otherodontogenic tumors
dc.subject.otherTherapy
dc.titleMolecular alterations in odontogenic keratocysts as potential therapeutic targets
dc.typeArtigo de periódico
local.citation.epage882
local.citation.issue10
local.citation.spage877
local.citation.volume46
local.description.resumoThe odontogenic keratocyst (OKC) is a cystic lesion, lined by uniformly thickened parakeratinized epithelium. Some lesions are large and tend to recur after surgical treatment. The neoplastic nature of OKCs remains a matter of dispute. It is known that some sporadic OKCs harbor PTCH1 mutations, and via the dissection of cyst epithelium, these mutations were demonstrated to occur much more frequently than previously thought. In addition to the classical PTCH1 mutations, Hedgehog pathway disturbance and Bcl-2 protein overexpression, as detected via genome-wide expression analysis of OKCs, have been published. Changes in DNA methylation patterns and alterations in microRNA expression levels have recently been reported in these lesions. We reviewed the molecular mechanisms that underlie the pathogenesis of OKCs as described over the past few years and explored the molecular alterations that can be therapeutically targeted.
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0002-1022-0336
local.identifier.orcidhttps://orcid.org/0000-0002-4212-1172
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12591

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