Developmental exposure to the flame retardant mixture firemaster 550 compromises adult bone integrity in male but not female rats

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dc.creatorSoraia Macari
dc.creatorKylie D. Rock
dc.creatorMariana S. Santos
dc.creatorVirgínia T. M. Lima
dc.creatorRaphael Escorsim Szawka
dc.creatorJamal Moss
dc.creatorBrian Horman
dc.creatorHeather B. Patisaul
dc.date.accessioned2023-07-14T20:10:47Z
dc.date.accessioned2025-09-08T23:24:24Z
dc.date.available2023-07-14T20:10:47Z
dc.date.issued2020
dc.identifier.doihttps://doi.org/10.3390/ijms21072553
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/1843/56277
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsAcesso Aberto
dc.subjectEndocrinologia
dc.subjectTecido adiposo
dc.subjectSexo - Diferenças
dc.subject.otherObesogen
dc.subject.otherEndocrine disrupting chemicals
dc.subject.otherEndocrine disrupting chemicals
dc.subject.otherAdipose
dc.subject.otherCortical bone
dc.subject.otherPPAR gamma
dc.subject.otherSex difference
dc.titleDevelopmental exposure to the flame retardant mixture firemaster 550 compromises adult bone integrity in male but not female rats
dc.typeArtigo de periódico
local.citation.epage12
local.citation.issue7
local.citation.spage1
local.citation.volume21
local.description.resumoFlame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate FRs (OPFRs) are becoming more prevalent as older, brominated FRs are phased out, but the toxicity of these compounds, and the FR mixtures that contain them, is poorly understood. Work in a variety of in vitro model systems has suggested that FRs may induce metabolic reprogramming such that bone density is compromised at the expense of increasing adiposity. To address this hypothesis, the present studies maternally exposed Wistar rat dams orally across gestation and lactation to 1000 µg daily of the FR mixture Firemaster 550 (FM 550) which contains a mixture of brominated FRs and OPFRs. At six months of age, the offspring of both sexeswereexaminedforevidenceofcompromisedbonecomposition. Bonedensity,composition,and marrow were all significantly affected, but only in males. The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming. The severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration.
local.identifier.orcidhttps://orcid.org/0000-0001-7643-6589
local.identifier.orcidhttps://orcid.org/0000-0003-2954-1110
local.identifier.orcidhttps://orcid.org/0000-0002-2639-3469
local.identifier.orcidhttps://orcid.org/0000-0002-7924-1610
local.identifier.orcidhttps://orcid.org/0000-0003-1278-2890
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/1422-0067/21/7/2553

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