Hepatotoxic effect of Lafoensia pacari A. St. Hil. (Lythraceae) on a diet-induced obese mice model

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dc.creatorNatália Gonçalves Ribeiro
dc.creatorFabio Ribeiro dos Santos
dc.creatorJanaína Ribeiro Oliveira
dc.creatorAmanda Souto Machado
dc.creatorDeborah de Faria Lelis
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luís Sena Guimarães
dc.creatorLucyana Conceição Farias
dc.creatorSérgio Henrique Sousa Santos
dc.date.accessioned2023-05-05T12:49:44Z
dc.date.accessioned2025-09-08T23:24:02Z
dc.date.available2023-05-05T12:49:44Z
dc.date.issued2021-01-27
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.2174/0929866528666210127151803
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/52847
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein & Peptide Letters
dc.rightsAcesso Restrito
dc.subjectMetabolismo
dc.subjectObesidade
dc.subjectPlantas medicinais
dc.subjectQuímica vegetal
dc.subjectMatéria médica vegetal
dc.subjectHepatotoxicologia
dc.titleHepatotoxic effect of Lafoensia pacari A. St. Hil. (Lythraceae) on a diet-induced obese mice model
dc.typeArtigo de periódico
local.citation.epage787
local.citation.spage781
local.citation.volume28
local.description.resumoBackground: brazilian flora is rich in plants with medicinal properties, which though popular, has contributed to the development of a range of phytotherapic products that use plants to treat and cure diseases. However, studies that use Brazilian plants in the treatment of metabolic disorders are still scarce in the literature. Objective: the aim of this study was to analyze the effect of hepatotoxicity Lafoensia pacari on the metabolism of mice with obesity induced by a high-fat diet and to verify the phytochemical difference between the Lafoensia pacari bark of the trunk, leaves, and branches. Methods: the plant material was collected from April to May in the municipality of Bonito de Minas, MG, Brazil. Qualitative tests for the presence of secondary metabolite classes were performed for leaves, branches and bark of the trunk. Through histological analysis, we evaluated hepatocytes and cell lesions in the liver. Results: the comparative phytochemical analysis of the plant did not reveal alterations between the different plant parts. The phytochemical test showed that is preferable to use the leaves to make the extract to be applied, aiming to reduce the plant aggression. After treatment, greater changes were observed in the animals that received the high-fat diet and the hydroethanolic extract; the levels of AST, ALT, albumin and creatinine that were increased, thus demonstrating a possible toxicity. There were no significant differences in body weight. In the histological analysis, the animals without plant treatment displayed decreased liver weight and reduction in the inflammatory infiltrate. Conclusion: we conclude that Lafoensia pacari should be better evaluated for oral consumption and may cause liver damage.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/113729

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