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Effects of high-dose bisphenol a on the mouse oral mucosa: a possible link with oral cancers

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dc.creatorTatiana Fernandes Araujo Almeida
dc.creatorSicília Rezende Oliveira
dc.creatorJanine Mayra da Silva
dc.creatorAna Laura Fernandes de Oliveira
dc.creatorZenilda de Lourdes Cardeal
dc.creatorHelvécio Costa Menezes
dc.creatorJosé Messias Gomes
dc.creatorGabriel Henrique Campolina silva
dc.creatorCleida Aparecida Oliveira
dc.creatorSoraia Macari
dc.creatorGustavo Pompermaier Garlet
dc.creatorIvana Márcia Alves Diniz
dc.creatorAndréia Machado Leopoldino
dc.creatorTarcília Aparecida Silva
dc.date.accessioned2024-04-29T14:55:48Z
dc.date.accessioned2025-09-08T23:57:55Z
dc.date.available2024-04-29T14:55:48Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2021.117296
dc.identifier.issn1873-6424
dc.identifier.urihttps://hdl.handle.net/1843/67847
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEnvironmental Pollution
dc.rightsAcesso Restrito
dc.subjectCelulas - Cultura e meios de cultura.
dc.subjectTumores
dc.subjectEstrogenos
dc.subject.otherBisphenol A
dc.subject.otherMouth neoplasms
dc.subject.otherCell culture techniques
dc.subject.otherHistone acetylation
dc.subject.otherEstrogen
dc.titleEffects of high-dose bisphenol a on the mouse oral mucosa: a possible link with oral cancers
dc.typeArtigo de periódico
local.citation.volume286
local.description.resumoBisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. We evaluated the oral mucosa of mice chronically exposed to BPA (200 mg/L). The response of keratinocytes (NOK–SI) and Head and Neck (HN) Squamous Cell Carcinoma (SCC), HN12 and HN13 cell lines to BPA was examined. In vivo, BPA accumulated in oral tissues and caused an increase in epithelial proliferative activity. BPA disrupted the function of keratinocytes by altering pro-survival and proliferative pathways and the secretion of cytokines and growth factors. In tumor cells, BPA induced proliferative, invasive, pro-angiogenic, and epigenetic paths. Our data highlight the harmful effects of BPA on oral mucosa and, tumorigenic and non-tumorigenic cells. Additionally, BPA may be a modifier of oral cancer cell behavior by prompting a functional shift to a more aggressive phenotype.
local.identifier.orcidhttps://orcid.org/0000-0002-3216-5649
local.identifier.orcidhttps://orcid.org/0000-0002-8164-2122
local.identifier.orcidhttps://orcid.org/0000-0002-1473-7455
local.identifier.orcidhttps://orcid.org/0000-0003-1383-6299
local.identifier.orcidhttps://orcid.org/0000-0002-5759-612X
local.identifier.orcidhttps://orcid.org/0000-0001-9610-7846
local.identifier.orcidhttps://orcid.org/0000-0001-7643-6589
local.identifier.orcidhttps://orcid.org/0000-0002-5071-8382
local.identifier.orcidhttps://orcid.org/0000-0003-4261-0037
local.identifier.orcidhttps://orcid.org/0000-0002-8313-4754
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0269749121008782

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