Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma

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dc.creatorCarla Mosconi
dc.creatorDiego Antônio Costa Arantes
dc.creatorAndréia Souza Gonçalves
dc.creatorRita de Cássia Gonçalves Alencar
dc.creatorJosé Carlos Oliveira
dc.creatorTarcília Aparecida da Silva
dc.creatorElismauro Francisco Mendonça
dc.creatorAline Carvalho Batista
dc.date.accessioned2025-04-02T19:07:18Z
dc.date.accessioned2025-09-08T23:54:15Z
dc.date.available2025-04-02T19:07:18Z
dc.date.issued2017-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2017.07.004
dc.identifier.issn1879-1506
dc.identifier.urihttps://hdl.handle.net/1843/81245
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Oral Biology
dc.rightsAcesso Restrito
dc.subjectHLA antigens
dc.subjectImmune evasion
dc.subjectCarcinoma, mucoepidermoid
dc.subjectB7-H1 antigen
dc.subjectSalivary gland neoplasms
dc.subjectEvaluation Study
dc.subjectCell count
dc.subjectImmunohistochemistry
dc.subjectHistology
dc.subjectProteins
dc.subject.otherHLA antigens
dc.subject.otherImmune evasion
dc.subject.otherMucoepidermoid carcinoma
dc.subject.otherSalivary gland neoplasms
dc.subject.otherProgrammed cell death 1 ligand 1
dc.titleImmunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma
dc.typeArtigo de periódico
local.citation.epage62
local.citation.spage55
local.citation.volume83
local.description.resumoObjective: To identify the expression of nonclassical human leukocyte antigen G and E (HLA-G and -E), programmed cell death ligand-1 (PD-L1) and granzyme B (GB) in intraoral mucoepidermoid carcinomas (MECs), and to assess whether such expressions are related to metastasis, survival, staging, tumor grade and number of GB-positive cells. Design: For this cross-sectional study, samples of MEC (n=30) were selected and classified as low-grade (LG), intermediate-grade (IG) or high-grade (HG), according to the WHO grading system. HLA-G, -E and PD-L1 were identified by immunohistochemistry and quantified as the proportion of positive neoplastic cells. The density of GB+ cells was also evaluated. The Kruskal-Wallis test was used with a 5% significance level. Results: Expressions of HLA-G, -E and PD-L1 were identified in the majority of epidermoid, intermediate and clear cells, but not in the mucous cells of the MECs. The quantitative analysis of the total percentage of positive neoplastic cells showed overexpression of this set of proteins in all MEC samples. The expression of these proteins and histological grading were positively correlated [HLA-G (LG=79% positive cells, IG=96%, HG=99%; p=0.0004), HLA-E (LG=70%, IG=96%, HG=99%; p<0.0001) and PD-L1 (LG=34%, IG=79%, HG=80%; p=0.01)]. No relationship was observed between the immunosuppressive proteins and other clinicopathological parameters. Low GB density was found in all MEC samples. Conclusions: The augmented expression of HLA-G, -E and PD-L1 in the intraoral MEC might suggest a role of these molecules in the scape of neoplastic cells from immunosurveillance.
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-8950-4605
local.identifier.orcidhttps://orcid.org/0000-0002-1306-747X
local.identifier.orcidhttps://orcid.org/0000-0003-1787-3521
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996917302169?via%3Dihub

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