Tupanvirus-infected amoebas are induced to aggregate with uninfected cells promoting viral dissemination

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dc.creatorGraziele Pereira Oliveira
dc.creatorLorena Silva
dc.creatorThiago Leão
dc.creatorSaid Mougari
dc.creatorFlávio Guimarães da Fonseca
dc.creatorErna Geessien Kroon
dc.creatorBernard la Scola
dc.creatorJônatas Santos Abrahão
dc.date.accessioned2025-02-17T17:57:10Z
dc.date.accessioned2025-09-09T00:22:06Z
dc.date.available2025-02-17T17:57:10Z
dc.date.issued2019-01-17
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-018-36552-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/80151
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectVírus Gigantes
dc.subjectInterações entre Hospedeiro e Microrganismos
dc.subjectVírus
dc.titleTupanvirus-infected amoebas are induced to aggregate with uninfected cells promoting viral dissemination
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.citation.volume9
local.description.resumoThe discovery of giant viruses in the last years has fascinated the scientific community due to virus particles size and genome complexity. Among such fantastic discoveries, we have recently described tupanviruses, which particles present a long tail, and has a genome that contains the most complete set of translation-related genes ever reported in the known virosphere. Here we describe a new kind of virus-host interaction involving tupanvirus. We observed that tupanvirus-infected amoebas were induced to aggregate with uninfected cells, promoting viral dissemination and forming giant host cell bunches. Even after mechanical breakdown of bunches, amoebas reaggregated within a few minutes. This remarkable interaction between infected and uninfected cells seems to be promoted by the expression of a mannose receptor gene. Our investigations demonstrate that the pre-treatment of amoebas with free mannose inhibits the formation of bunches, in a concentration-dependent manner, suggesting that amoebal-bunch formation correlates with mannose receptor gene expression. Finally, our data suggest that bunch-forming cells are able to interact with uninfected cells promoting the dissemination and increase of tupanvirus progeny.
local.identifier.orcidhttps://orcid.org/0000-0002-8521-0351
local.identifier.orcidhttps://orcid.org/0000-0003-2272-4141
local.identifier.orcidhttps://orcid.org/0000-0002-9319-5454
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0001-8006-7704
local.identifier.orcidhttps://orcid.org/0000-0001-9420-1791
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-018-36552-4#rightslink

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