The renin angiotensin system and bipolar disorder: a systematic review

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dc.creatorIzabela Guimarães Barbosa
dc.creatorGiulia Campos Ferreira
dc.creatorDiomildo Ferreira Andrade Júnior
dc.creatorCássio Rocha Januário
dc.creatorAndré Rolim Belisário
dc.creatorMoises Evandro Bauer
dc.creatorAna Cristina Simões e Silva
dc.date.accessioned2023-07-17T22:12:32Z
dc.date.accessioned2025-09-08T23:24:25Z
dc.date.available2023-07-17T22:12:32Z
dc.date.issued2019-11-16
dc.format.mimetypepdf
dc.identifier.doi10.2174/0929866527666200127115059
dc.identifier.issn09298665
dc.identifier.urihttps://hdl.handle.net/1843/56551
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein & Peptide Letters
dc.rightsAcesso Restrito
dc.subjectSistema Renina-Angiotensina
dc.subjectTranstorno Bipolar
dc.subjectMania
dc.subjectDepressão
dc.subject.otherRenin angiotensin system
dc.subject.otherAngiotensin peptides
dc.subject.otherBipolar disorder
dc.subject.otherMania
dc.subject.otherDepression
dc.subject.otherPlasma renin activity
dc.titleThe renin angiotensin system and bipolar disorder: a systematic review
dc.typeArtigo de periódico
local.citation.epage528
local.citation.spage520
local.citation.volume27
local.description.resumoAbstract: Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttp://www.eurekaselect.com/article/103923

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