Stability indicating method for a thiazolylhydrazone derivative with antifungal activity and experimental/theoretical elucidation of its degradation products

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dc.creatorIara Rinco Silva
dc.creatorVinícius Gonçalves Maltarollo
dc.creatorÍcaro Ferrari Protti
dc.creatorRenata Barbosa de Oliveira
dc.creatorIsabela da Costa César
dc.date.accessioned2025-02-04T17:59:35Z
dc.date.accessioned2025-09-09T01:31:54Z
dc.date.available2025-02-04T17:59:35Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.21577/0103-5053.20220131
dc.identifier.issn0103-5053
dc.identifier.urihttps://hdl.handle.net/1843/79654
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rightsAcesso Aberto
dc.subjectQuímica quântica
dc.subjectAntígenos de fungos
dc.subjectQuímica
dc.subject.otherStability indicating method
dc.subject.otherHPLC
dc.subject.otherForced degradation
dc.subject.otherQuantum mechanics calculations
dc.titleStability indicating method for a thiazolylhydrazone derivative with antifungal activity and experimental/theoretical elucidation of its degradation products
dc.typeArtigo de periódico
local.citation.epage581
local.citation.issue4
local.citation.spage571
local.citation.volume34
local.description.resumoRN104 (2-[2-(cyclohexylmethylene)hydrazinyl]-4-phenylthiazole) is a thiazolylhydrazone derivative with promising in vitro and in vivo antifungal activity. A stability indicating highperformance liquid chromatography with diode-array detection (HPLC-DAD) method was carried out using C18 end-capped column (250 × 4.6 mm, 5 μm) and a mobile phase composed of water and acetonitrile (15:85 v/v) at a flow rate of 1.2 mL min-1, injection volume 25 μL and DAD detection at 240 nm. The method showed to be selective, linear in the range of 20 to 240 μg mL-1, precise, accurate and robust. RN104 forced degradation study under different stress conditions (acidic, alkaline and neutral hydrolysis, oxidation, photolysis and thermolysis) was performed using the validated analytical method. The results showed that RN104 underwent significant degradation when subjected to alkaline hydrolysis and oxidation by metallic ions. Quantum mechanics calculations were carried out to assist in the structural elucidation of the formed degradation products. The obtained data may be useful for the development of future formulation based on RN104.
local.identifier.orcidhttps://orcid.org/0000-0001-9675-5907
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentFARMACIA - FACULDADE DE FARMACIA
local.publisher.initialsUFMG
local.url.externahttps://jbcs.sbq.org.br/default.asp?ed=337

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