Adipokines, inflammatory and insulin resistance parameters may not be good markers of metabolic syndrome following liver transplant

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dc.creatorLucilene Rezende Anastácio
dc.creatorMarina Chaves de Oliveira
dc.creatorKiara Gonçalves Diniz
dc.creatorAdaliene Matos Versiane Ferreira
dc.creatorAgnaldo Soares Lima
dc.creatorMaria Isabel Toulson Davisson Correia
dc.creatorEduardo Garcia Vilela
dc.date.accessioned2022-02-23T23:59:13Z
dc.date.accessioned2025-09-09T01:16:42Z
dc.date.available2022-02-23T23:59:13Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.nut.2015.12.038
dc.identifier.issn08999007
dc.identifier.urihttps://hdl.handle.net/1843/39631
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofNutrition
dc.rightsAcesso Restrito
dc.subjectTransplante
dc.subjectFígado
dc.subject.otherLiver transplantation
dc.subject.otherMetabolic syndrome
dc.subject.otherObesity
dc.subject.otherAdipokines
dc.subject.otherInsulin resistance
dc.titleAdipokines, inflammatory and insulin resistance parameters may not be good markers of metabolic syndrome following liver transplant
dc.typeArtigo de periódico
local.citation.epage927
local.citation.issue9
local.citation.spage921
local.citation.volume32
local.description.resumoObjective The role of adipokines in liver transplantation (LTx) recipients who have metabolic syndrome (MetS) has seldom been assessed. The aim of this study was to investigate the concentrations of adipokines, inflammatory mediators, and insulin-resistance markers in liver recipients with MetS and its components. Methods Serum samples from 34 patients (55.9% male; 54.9 ± 13.9 y; 7.7 ± 2.9 y after LTx; 50% presented with MetS) were assessed for adiponectin, resistin, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6, C-reactive protein (CRP), homeostatic model assessment-insulin resistance (HOMA-IR) and free fatty acid (FFA) levels. The dosages were uni- and multivariate analyzed to cover MetS (using the Harmonizing MetS criteria), its components, and dietary intake. Results A higher concentration of adiponectin (P < 0.05) was observed among patients with MetS (5.2 ± 3.2 μg/mL) compared with those without MetS (3.2 ± 1.2 μg/mL), as well as those with MetS components versus those without them: abdominal obesity (4.6 ± 2.6 μg/mL versus 2.6 ± 0.6 μg/mL), high triacylglycerols (TGs; 5.6 ± 3.1 μg/mL versus 3 ± 0.9 μg/mL) and low high-density lipoprotein (HDL; 6.1 ± 2.7 μg/mL versus 3.3 ± 1.9 μg/mL). Increased TNF-α and HOMA-IR values were seen in patients with abdominal obesity. Patients with high TGs also had greater FFA values. Independent predictors for adiponectin were waist-to-hip ratio, low HDL and high TGs. High TGs and fasting blood glucose were independent predictors for HOMA-IR. Independent predictors could not be identified for CRP, TNF-α, MCP-1, IL-6, or FFA. Conclusions MetS and its components are related to an increased HOMA-IR concentration and FFA. Adiponectin, resistin, and inflammatory markers, such as TNF-α, IL-6, MCP-1, and CRP, were not associated with MetS in this sample of post-LTx patients.
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0899900715005353?via%3Dihub

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