Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample

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dc.creatorRenalice Neves Vieira
dc.creatorLuiz Armando de Marco
dc.creatorMarco Aurélio Romano-Silva
dc.creatorMaria Aparecida Camargos Bicalho
dc.creatorRafaela Ávila
dc.creatorJonas Jardim de Paula
dc.creatorMarco Túlio Gualberto Cintra
dc.creatorRenan Pedra de Souza
dc.creatorRodrigo Nicolato
dc.creatorLeandro Malloy-Diniz
dc.creatorDébora Marques de Miranda
dc.creatorEdgar Nunes de Moraes
dc.date.accessioned2023-08-07T19:08:51Z
dc.date.accessioned2025-09-08T22:53:56Z
dc.date.available2023-08-07T19:08:51Z
dc.date.issued2016
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/gps.4440
dc.identifier.issn0885-6230
dc.identifier.urihttps://hdl.handle.net/1843/57562
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Journal of Geriatric Psychiatry
dc.rightsAcesso Restrito
dc.subjectDoença de Alzheimer
dc.subjectDisfunção Cognitiva
dc.subject.otherAlzheimer’s disease
dc.subject.otherMild cognitive impairment
dc.titleAssociation between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample
dc.typeArtigo de periódico
local.citation.epage1344
local.citation.issue12
local.citation.spage1337
local.citation.volume31
local.description.resumoObjectives: In 2012, Kamboh and colleagues published a genome-wide association study that identified the DCHS2 gene (rs1466662 T/A) influencing the age at onset of Alzheimer’s disease (AD). We aimed to investigate if there is association between the DCHS2 gene and amnestic mild cognitive impairment (aMCI) and AD in a sample of the Brazilian population. Methods: 143 controls, 79 aMCI and 299 AD patients were selected and submitted to the same protocol of tests. Genotyping was performed using the Real Time PCR Results: Amnestic MCI patients showed a higher prevalence of AA than controls and a lower frequency of TT when compared with controls. We also stratified the sample according to the APOE ε4 status. No difference in DCHS2 genotype or allelic frequency occurred in the APOE ε4 allele carrier subgroup. Amnestic MCI patients showed a higher frequency of AA genotype and a lower frequency of TA and TT when compared with controls in APOE ε4 allele non-carrier subgroup. The allelic distribution followed the same pattern. In AD group, we observed a significant difference with a higher A allelic frequency in AD in this subgroup. A multiple logistic regression demonstrated that in APOE ε4 non-carriers, allele rs1466662 was associated to aMCI group. Different variables were associated with aMCI and AD according to APOE ε4 status in our sample. Low level of education was associated with AD, while diabetes mellitus type 2 was associated with aMCI. Conclusions: Our findings suggest a possible role for DCHS2 gene in aMCI and AD.
local.identifier.orcidhttps://orcid.org/0000-0003-3089-655X
local.publisher.countryBrasil
local.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/gps.4440

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