Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against zika virus infection?

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dc.creatorAna Paula Valente
dc.creatorAdolfo Henrique de Moraes Silva
dc.date.accessioned2022-10-18T19:22:13Z
dc.date.accessioned2025-09-08T23:05:19Z
dc.date.available2022-10-18T19:22:13Z
dc.date.issued2019-08-29
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1678-9199-JVATITD-2019-0013
dc.identifier.issn1678-9199
dc.identifier.urihttps://hdl.handle.net/1843/46332
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rightsAcesso Aberto
dc.subjectProteínas virais
dc.subjectProteínas
dc.subjectBiologia
dc.subjectEspectroscopia de ressonancia nuclear
dc.subject.otherZika virus proteins
dc.subject.otherStructural biology
dc.subject.otherProtein structure
dc.subject.otherNuclear magnetic resonance spectroscopy
dc.subject.otherProtein-antibody interaction
dc.subject.otherProtein-small compound interaction
dc.titleZika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against zika virus infection?
dc.typeArtigo de periódico
local.citation.spagee20190013
local.citation.volume25
local.description.resumoIn Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barré syndrome in adults. Recently, research has been focused on developing new vaccines and drug candidates against Zika virus infection since none of those are available. In order to contribute to vaccine and drug development efforts, it becomes important the understanding of the molecular basis of the Zika virus recognition, infection and blockade. To this purpose, it is essential the structural determination of the Zika virus proteins. The genome sequencing of the Zika virus identified ten proteins, being three structural (protein E, protein C and protein prM) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5). Together, these proteins are the main targets for drugs and antibody recognition. Here we examine new discoveries on high-resolution structural biology of Zika virus, observing the interactions and functions of its proteins identified via state-of-art structural methodologies as X-ray crystallography, nuclear magnetic resonance spectroscopy and cryogenic electronic microscopy. The aim of the present study is to contribute to the understanding of the structural basis of Zika virus infection at an atomic level and to point out similarities and differences to others flaviviruses.
local.identifier.orcidhttps://orcid.org/0000-0002-3344-4084
local.identifier.orcidhttps://orcid.org/0000-0001-7219-1123
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jvatitd/a/WV8JCNrNvVw5SK7BTFrGXXC/

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