A proposal for classification of oropharyngeal squamous cell carcinoma: morphology and status of by immunohistochemistry and molecular biology

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dc.creatorSiavash Rahimi
dc.creatorIolia Akaev
dc.creatorPeter A Brennan
dc.creatorAzarel Virgo
dc.creatorCarla Marani
dc.creatorRicardo Santiago Gomez
dc.creatorChit Cheng Yeoh
dc.date.accessioned2025-01-30T13:12:06Z
dc.date.accessioned2025-09-09T00:37:38Z
dc.date.available2025-01-30T13:12:06Z
dc.date.issued2020-02
dc.identifier.doihttps://doi.org/10.1111/jop.12956
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/79540
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectCarcinoma
dc.subjectSquamous cell carcinoma of head and neck
dc.subjectHuman papillomavirus viruses
dc.subjectOropharynx
dc.subjectClassification
dc.subjectEvaluation study
dc.subjectPapillomavirus infections
dc.subjectSurvival
dc.subjectImmunohistochemistry
dc.subject.otherCarcinoma
dc.subject.otherHead and neck squamous cell carcinoma
dc.subject.otherHuman papilloma virus
dc.subject.otherOropharynx
dc.subject.otherP16
dc.subject.otherSquamous
dc.titleA proposal for classification of oropharyngeal squamous cell carcinoma: morphology and status of by immunohistochemistry and molecular biology
dc.typeArtigo de periódico
local.citation.epage116
local.citation.issue2
local.citation.spage110
local.citation.volume49
local.description.resumoThe current three-tier grading system (well, moderate and poorly differentiated) used to morphologically classify head and neck squamous cell carcinoma (HNSCC) is inadequate for categorisation of oropharyngeal squamous cell carcinoma (OPSCC) owing to the lack of prognostic value. The aim of this study was to assess the validity of a classification system for OPSCC based on morphology and human papilloma virus (HPV) infection status. Haematoxylin and eosin slides of 121 patients (100 M, 21 F, age range 40-89 years) with OPSCC were reviewed and categorised as histological types I, II and III. The presence of HPV was assessed by immunohistochemistry with p16 and RNAscope In situ hybridization (ISH). The follow-up period was 36 months. Ninety-six patients were p16+ and clinical stage I. Patient survival with types I, II and III was 93%, 50% and 96%, respectively. Twenty-five patients were p16-: 10 clinical stage I and 15 stage III. Amongst this group, no type I morphology was identified. At follow-up, 65% of type II and 75% of type III patients were alive. All p16+ cases were also positive for E6/E7 mRNA high-risk HPV by ISH, while 23 p16- cases were negative and two were positive. Cox regression identified three predictors of mortality: older age (HR = 1.14, 95% CI = 1.06-1.23, P = .001); female gender (HR = 0.22.95% CI 0.05-0.88, P = .033); and type II morphology (HR = 13.1, 95% CI = 1.09-157.0, P = .043). OPSCC morphological classification in three sub-types, along with HPV infection status, seems to reflect the outcome of patients with OPSCC.
local.identifier.orcidhttps://orcid.org/0000-0002-4351-8147
local.identifier.orcidhttps://orcid.org/0000-0003-4804-3264
local.identifier.orcidhttps://orcid.org/0000-0003-1199-0372
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.identifier.orcidhttps://orcid.org/0000-0001-6026-9843
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.12956

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