Association of nitric oxide with oral lichen planus

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dc.creatorAbdul Wahab Alamir
dc.creatorGururaj Arakeri
dc.creatorShankargouda Patil
dc.creatorKamran Habib Awan
dc.creatorOmar Kujan
dc.creatorAbdulsalam Aljabab
dc.creatorFelipe Paiva Fonseca
dc.creatorPeter Brennan
dc.date.accessioned2023-11-10T21:20:25Z
dc.date.accessioned2025-09-09T00:06:51Z
dc.date.available2023-11-10T21:20:25Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1111/jop.12837
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/60821
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectBiomarkers
dc.subjectNitric oxide
dc.subjectLichen planus, oral
dc.subjectSystematic review
dc.subjectAssociation
dc.titleAssociation of nitric oxide with oral lichen planus
dc.typeArtigo de periódico
local.citation.epage350
local.citation.issue5
local.citation.spage345
local.citation.volume48
local.description.resumoBackground: The small signalling molecule nitric oxide (NO) has been postulated to have a mediator role in the pathogenesis of several diseases including oral lichen planus (OLP). This systematic review aimed to quantify the existing literature and assess the association of NO and OLP. Methods: The focused question being addressed was "Is there an association between nitric oxide and OLP?" PubMed, EMBASE, Scopus, and Web of Science, and grey literature from January 1990 to August 2018 were searched. Two independent reviewers performed the study selection using specified eligibility criteria. Results: Seven studies that met the eligibility criteria were included. All of these were case-control studies and 151 patients with OLP were evaluated (mostly females), with an age ranged from 20 to 75 years. The included studies showed a significant higher NO levels in OLP patients compared to the healthy controls, with two studies demonstrated a higher NO levels in erosive OLP compared to non-erosive OLP. Conclusion: These findings support that an association exists between higher NO concentration and OLP. However, larger high-quality studies with refined methodological design are needed to confirm the role of NO in the aetiology and pathogenesis of OLP
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12837

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