Tacrolimus action pathways in an ointment base for hypertrophic scar prevention in a rabbit ear model

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dc.creatorMariana Campos Souza Menezes
dc.creatorMarcelo Buzelin
dc.creatorCristiana Buzelin Nunes
dc.creatorLuiz Ronaldo Alberti
dc.date.accessioned2023-05-15T19:44:01Z
dc.date.accessioned2025-09-08T23:27:49Z
dc.date.available2023-05-15T19:44:01Z
dc.date.issued2021-05-15
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.abd.2020.08.019
dc.identifier.issn03650596
dc.identifier.urihttps://hdl.handle.net/1843/53387
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsAcesso Aberto
dc.subjectTacrolimo
dc.subjectCicatriz Hipertrófica
dc.subjectQueloide
dc.subjectFator A de Crescimento do Endotélio Vascular
dc.subject.otherHypertrophic scar
dc.subject.otherKeloid
dc.subject.otherTacrolimus
dc.subject.otherVascular endothelial growth factor
dc.titleTacrolimus action pathways in an ointment base for hypertrophic scar prevention in a rabbit ear model
dc.typeArtigo de periódico
local.citation.epage435
local.citation.issue4
local.citation.spage429
local.citation.volume96
local.description.resumoBackground: Tacrolimus is used to prevent unaesthetic scars due to its action on fibroblast activity and collagen production modulation. Objectives: To evaluate the action pathways, from the histopathological point of view and in cytokine control, of tacrolimus ointment in the prevention of hypertrophic scars. Methods: Twenty-two rabbits were submitted to the excision of two 1-cm fragments in each ear, including the perichondrium. The right ear received 0.1% and 0.03% tacrolimus in ointment base twice a day in the upper wound and in the lower wound respectively. The left ear, used as the control, was treated with petrolatum. After 30 days, collagen fibers were evaluated using special staining, and immunohistochemistry analyses for smooth muscle actin, TGF- and VEGF were performed. Results: The wounds treated with 0.1% tacrolimus showed weak labeling and a lower percentage of labeling for smooth muscle actin, a higher proportion of mucin absence, weak staining, fine and organized fibers for Gomori’s Trichrome, strong staining and organized fibers for Verhoeff when compared to controls. The wounds treated with 0.03% tacrolimus showed weak labeling for smooth muscle actin, a higher proportion of mucin absence, strong staining for Verhoeff when compared to the controls. There was absence of TGF- and low VEGF expression. Study limitations: The analysis was performed by a single pathologist. Second-harmonic imaging microscopy was performed in 2 sample areas of the scar.
local.identifier.orcidhttps://orcid.org/0000-0002-5266-6870
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0365059621001264?via%3Dihub

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