Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?

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dc.creatorGustavo Cancela e Penna
dc.creatorCamila Teixeira Costa
dc.creatorMagda Carvalho Pires
dc.creatorTarcizo Afonso Nunes
dc.date.accessioned2023-04-27T19:53:58Z
dc.date.accessioned2025-09-08T23:05:22Z
dc.date.available2023-04-27T19:53:58Z
dc.date.issued2021-09-29
dc.description.abstractObjetivo: Analisar a associação das características clínicas, anatômicas e ultrassonográficas (US) das neoplasias em nódulos tireoidianos Bethesda III ou IV (III-B ou IV-B). Sujeitos e métodos: Foi analisada a associação entre malignidades e as seguintes variáveis: III-B ou IV-B, idade < 55 anos e ≥ 55 anos, sexo, história familiar de câncer de tireoide, história de irradiação, tamanho do nódulo e ACR TI -Classificação RADS em 62 participantes submetidos à tireoidectomia. Resultados: Dos 62 participantes, 87,1% (54/62) eram mulheres, 74,2% tinham < 55 anos, 95,2% não tinham histórico familiar de câncer de tireoide, 56,5% tinham nódulos < 2 cm de tamanho, 62,9% eram IV- B, e 69,4% eram ACR TI-RADS 4. Trinta e dois pacientes tinham carcinoma de tireoide e 30 tinham histologia benigna. Entre todos os fatores associados à malignidade, apenas a classificação ACR TI-RADS 5 na US foi estatisticamente significativa (p = 0,014), enquanto a classificação citológica III-B com atipia arquitetônica foi a única significativamente associada ao estado benigno (p = 0,004 ). Conclusão: Somente o alto risco de malignidade avaliado pela US foi capaz de refinar a indicação de testes moleculares em um grupo de pacientes com nódulos indeterminados. Descobrimos que 85% (53/62) dos nódulos tireoidianos III-B ou IV-B se beneficiariam com os testes de diagnóstico molecular disponíveis.
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.20945/2359-3997000000402
dc.identifier.issn2359-4292
dc.identifier.urihttps://hdl.handle.net/1843/52612
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsAcesso Aberto
dc.subjectNódulo da glândula tireoide
dc.subjectTécnicas de diagnóstico molecular
dc.subjectNeoplasias
dc.subject.otherThyroid nodules
dc.subject.otherIndeterminate nodules
dc.subject.otherIndeterminate thyroid nodules
dc.subject.otherMolecular tests
dc.subject.otherMolecular diagnostic tests
dc.titleAre the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?
dc.title.alternativeSão os aspectos anatômicos, clínicos e características ultrassonográficas de nódulos da tireoide com Bethesda III ou IV citologia e ACR TI-RADS 3, 4 ou 5 capaz de refinar as indicações para testes de diagnóstico molecular?
dc.typeArtigo de periódico
local.citation.epage631
local.citation.issue5
local.citation.spage625
local.citation.volume65
local.description.resumoObjective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy. Results: Of the 62 participants, 87.1% (54/62) were women, 74.2% were < 55 years old, 95.2% had no family history of thyroid cancer, 56.5% had nodules < 2 cm in size, 62.9% were IV-B, and 69.4% were ACR TI-RADS 4. Thirty-two patients had thyroid carcinoma, and 30 had benign histology. Among all factors associated with malignancy, only ACR TI-RADS 5 classification on US was found to be statistically significant (p = 0.014), while III-B with architectural atypia cytological classification was the only one significantly associated with benign status (p = 0.004). Conclusion: Only a high risk of malignancy as assessed using US was able to refine the indication for molecular tests in a group of patients with indeterminate nodules. We found 85% (53/62) of III-B or IV-B thyroid nodules would benefit from available molecular diagnostic tests.
local.identifier.orcidhttps://orcid.org/0000-0003-2125-7051
local.identifier.orcidhttps://orcid.org/0000-0003-3227-1799
local.identifier.orcidhttps://orcid.org/0000-0003-3312-4002
local.identifier.orcidhttps://orcid.org/0000-0001-7971-5786
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://www.aem-sbem.com/article/are-the-anatomical-clinical-and-ultrasound-characteristics-of-thyroid-nodules-with-bethesda-iii-or-iv-cytology-and-acr-ti-rads-3-4-or-5-able-to-refine-the-indications-for-molecular-diagnostic-test/

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