Functionalization of poly(lactic-co-glycolic acid) nanofibrous membranes with antibiofilm compounds

Página do item simplificado
dc.creatorThaise Cristina Geremias
dc.creatorMarcos Antônio Batistella
dc.creatorRicardo de Souza Magini
dc.creatorSelene Maria de Arruda Guelli Ulson de Souza
dc.creatorVitorio Franco
dc.creatorLuiz Cláudio de Almeida Barbosa
dc.creatorUlisses Alves Pereira
dc.creatorJuan Paulo Hinestroza
dc.creatorAndrea de Lima Pimenta
dc.creatorAntônio Augusto Ulson de Souza
dc.date.accessioned2023-11-30T15:30:40Z
dc.date.accessioned2025-09-09T00:23:24Z
dc.date.available2023-11-30T15:30:40Z
dc.date.issued2021-03-16
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1002/cjce.24115
dc.identifier.issn1939-019X
dc.identifier.urihttps://hdl.handle.net/1843/61559
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofThe Canadian Journal of Chemical Engineering
dc.rightsAcesso Restrito
dc.subjectLactamas
dc.subjectBiofilme
dc.subjectStreptococcus mutans
dc.subjectEssências e óleos essenciais
dc.subject.otherantibiofilme bacteriano
dc.subject.otherbacterial adhesion
dc.subject.otherelectrospinning
dc.subject.otherquorum sensing
dc.titleFunctionalization of poly(lactic-co-glycolic acid) nanofibrous membranes with antibiofilm compounds
dc.typeArtigo de periódico
local.citation.epageS15
local.citation.issueS1
local.citation.spageS5
local.citation.volume100
local.description.resumoThe aim of this research was to investigate the activity of functionalized PLGA electrospun membranes in preventing Streptococcus mutans biofilm formation. PLGA nanofibres were functionalized with the additives Melaleuca alternifolia and Coffea canephora essential oils, furan-2(5H)-one, and a novel synthetic butyrolactam, in three concentrations (0.002%, 0.004%, and 0.008% w/v). Samples were characterized by SEM, FTIR-ATR, and GC–MS and exposed to S. mutans cultures. Planktonic growth was determined following a 24- and 48-h incubation period by spectrophotometry and the biofilm formation was evaluated by counting colony forming units. Cytotoxicity of the new biomaterials was assessed by MTS assay, through the quantification of viable placenta-derived stem cells grown over the functionalized nanofibrous membranes. Observation of the electrospun membranes on SEM images revealed the smooth and bead-free morphology of the nanofibres. No solvent residues were observed by FTIR-ATR, but the GC–MS results showed that N,N-dimethylformamide and dimethylsulfoxide were present as residues in the membranes after functionalization. Functionalization reduced bacterial attachment to membrane surfaces, with best results being obtained for M. alternifolia essential oil, furanone, and butyrolactam. Cytotoxicity results showed that furan-2(5H)-one-functionalized membranes demonstrated no statistically significant difference in the cell viability compared to the control membranes.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/cjce.24115

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG