CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

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dc.creatorLuan César da Silva
dc.creatorFelipe Paiva Fonseca
dc.creatorOslei Paes de Almeida
dc.creatorBruno Augusto Linhares de Almeida Mariz
dc.creatorMárcio Ajudarte Lopes
dc.creatorRaghu Radhakrishnan
dc.creatorMohit Sharma
dc.creatorLuiz Paulo Kowalski
dc.creatorPablo Agustin Vargas
dc.date.accessioned2024-01-30T17:48:09Z
dc.date.accessioned2025-09-09T00:06:47Z
dc.date.available2024-01-30T17:48:09Z
dc.date.issued2019-12-24
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.23177
dc.identifier.issn16986946
dc.identifier.urihttps://hdl.handle.net/1843/63531
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMedicina oral patología oral y cirugía bucal
dc.rightsAcesso Aberto
dc.subjectNeoplasms
dc.subjectOral submucous fibrosis
dc.subjectCarcinoma, squamous cell
dc.subjectImmunity
dc.subjectDendritic cells
dc.subjectLeukoplakia, oral
dc.subjectLangerhans cells
dc.subjectAntigens
dc.titleCD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epagee55
local.citation.issue1
local.citation.spagee49
local.description.resumoBackground: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982989/

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