Central giant cell lesion of the jaws: an updated analysis of 2270 cases reported in the literature

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dc.creatorBruno Ramos Chrcanovic
dc.creatorCarolina Cavalieri Gomes
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2025-07-22T17:41:51Z
dc.date.accessioned2025-09-09T01:30:27Z
dc.date.available2025-07-22T17:41:51Z
dc.date.issued2018-09
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12730
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/83746
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectGranuloma, giant cell
dc.subjectTherapeutics
dc.subjectRadiology
dc.subjectRecurrence
dc.subjectPrevalence
dc.subjectRoot resorption
dc.subjectGuidelines as topic
dc.subject.otherAggressiveness classification
dc.subject.otherCentral giant cell granuloma
dc.subject.otherCentral giant cell lesion
dc.subject.otherClinical features
dc.subject.otherRecurrence rate
dc.subject.otherTreatment
dc.titleCentral giant cell lesion of the jaws: an updated analysis of 2270 cases reported in the literature
dc.typeArtigo de periódico
local.citation.epage739
local.citation.issue8
local.citation.spage731
local.citation.volume47
local.description.resumoPurpose: To review all available data published on central giant cell lesion (CGCL) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with its recurrence. Methods: An electronic search was undertaken in 5 databases (February/2018), looking for reporting cases of CGCLs. Results: A total of 365 publications were included, comprising 2270 lesions. CGCLs were more prevalent in women and the mandible. Cortical bone perforation occurred in 50% of the cases. Marginal/segmental resection was more often performed in larger lesions, and drug therapy was more frequent in small lesions. Recurrence was reported in 232 of 1316 cases (17.6%). The recurrence rate of the aggressive lesions (22.8%) after surgical treatment was higher than non-aggressive lesions (7.8%). Four of 5 CGCLs showed partial/total regression with pharmacological treatment. Aggressive lesions showed a worse response to corticosteroids than non-aggressive lesions. For the lesions submitted to surgery as the first treatment, curettage, enucleation, or marginal resection in relation to segmental resection, aggressive lesions, cortical bone perforation, and tooth root resorption were associated with increased recurrence rate. Recurrence related to a combination of surgical/pharmacological treatment could not be evaluated due to the variety of protocols. Conclusions: Aggressive CGCLs recur more often than the non-aggressive ones. Despite sometimes showing poor response to corticosteroid injection or surgical curettage, a combination of both treatment strategies should be considered in aggressive cases to reduce morbidities associated with radical surgery. The best protocol to manage aggressive and non-aggressive lesions remains to be determined.
local.identifier.orcidhttps://orcid.org/0000-0002-3460-3374
local.identifier.orcidhttps://orcid.org/0000-0003-1580-4995
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://pubmed.ncbi.nlm.nih.gov/29751369/

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