Circulating irisin is increased in type 2 diabetes mellitus and correlates with fasting glucose levels

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dc.creatorKathryna Fontana Rodrigues
dc.creatorNathalia Teixeira Pietrani
dc.creatorAdriana Aparecida Bosco
dc.creatorCláudia Natália Ferreira
dc.creatorKarina Braga Gomes Borges
dc.date.accessioned2022-03-17T13:58:04Z
dc.date.accessioned2025-09-09T00:00:29Z
dc.date.available2022-03-17T13:58:04Z
dc.date.issued2016
dc.identifier.doihttps://doi.org/10.1016/j.apme.2016.02.010
dc.identifier.issn0976-0016
dc.identifier.urihttps://hdl.handle.net/1843/40176
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofApollo Medicine
dc.rightsAcesso Restrito
dc.subjectDiabetes mellitus tipo 2
dc.subjectObesidade
dc.subjectGlucose
dc.subjectMetabolismo
dc.subjectExercício físico
dc.subject.otherIrisin
dc.subject.otherType 2 diabetes mellitus
dc.subject.otherObesity
dc.subject.otherGlucose metabolism
dc.subject.otherPhysical activity
dc.titleCirculating irisin is increased in type 2 diabetes mellitus and correlates with fasting glucose levels
dc.typeArtigo de periódico
local.citation.epage155
local.citation.issue3
local.citation.spage152
local.citation.volume13
local.description.resumoBackground/aims: Irisin is a hormone expressed in muscle, which is an exercise-induced myokine triggering browning of white adipose tissue and increases metabolic genes expression. Methods: We investigated the irisin levels in 39 type 2 diabetes mellitus patients (T2D) compared to 39 control individuals.Results: Irisin plasma levels were higher in T2D patients when compared with the control group (p < 0.0001). Non-obese T2D individuals presented higher irisin levels when compared with non-obese and obese controls (p < 0.0001 and p = 0.011, respectively). Obese T2D individuals showed higher irisin levels when compared with non-obese control (p = 0.003), but no difference was observed when compared with obese controls (p > 0.05). A positive correlation was observed between irisin and fasting glucose levels in the T2D group (r = 0.341, p = 0.033). No difference regarding irisin levels was found when T2D individuals who practice physical activity and sedentary individuals were compared (p = 0.632). Conclusion: This result indicates that T2D is associated with an irisin release in order to compensate the insulin resistance observed in the skeletal muscle on diabetes, and that the poor glycaemic control contributes for enhancement of this state.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0976001616000259

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