Radiation therapy reduced blood levels of LDH, HIF-1α, and miR-210 in OSCC

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dc.creatorMarcela Gonçalves de Souza
dc.creatorSabrina Ferreira de Jesus
dc.creatorEloá Mangabeira Santos
dc.creatorEmisael Stênio Batista Gomes
dc.creatorArlen de Paulo Santiago Filho
dc.creatorEliane Macedo Sobrinho Santos
dc.creatorLuiz Henrique da Silveira
dc.creatorSergio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-22T13:24:41Z
dc.date.accessioned2025-09-08T23:52:44Z
dc.date.available2022-08-22T13:24:41Z
dc.date.issued2018-11-08
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doi10.1007/s12253-018-0517-2
dc.identifier.issn1532-2807
dc.identifier.urihttps://hdl.handle.net/1843/44433
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPathology and Oncology Research
dc.rightsAcesso Aberto
dc.subjectCâncer - Radioterapia
dc.subjectLactato desidrogenase
dc.subjectCarcinoma de células escamosas
dc.titleRadiation therapy reduced blood levels of LDH, HIF-1α, and miR-210 in OSCC
dc.typeArtigo de periódico
local.citation.epage442
local.citation.spage433
local.citation.volume26
local.description.resumoRadiation Therapy (RT) is a treatment option for a large number of neoplasias. However, the effect of RT on the level of hypoxia markers is poorly understood. The present study aimed to investigate the effect of RT on the levels of hypoxic markers in Oral squamous cell carcinoma (OSCC). Evaluation of HIF-1α and miR-210 levels in OSCC was performed. Then a proteomic analysis was performed to identify candidate hypoxic targets of RT. To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. The impact of RT in hypoxia markers was evaluated in patients to confirm in vitro results. An increase in the HIF-1α levels was observed in OSCC. RT reduced OSCC cell proliferation and migration. Interestingly, hypoxia could revert the effect of radiation on OSCC phenotype. However, proteomics analyses suggested that LDH is one of the critical targets of RT even in hypoxia. Moreover, RT decreased HIF-1α, miR-210, and LDH even in hypoxia. The current study demonstrated that hypoxia could revert the effects of RT in the OSCC context. However, RT reduces the levels HIF-1α, miR-210 and LDH in vivo and in vitro. The consequences of RT in blood should be carefully investigated.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12253-018-0517-2

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