Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity

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dc.creatorLetícia Márcia da Silva Tinoco
dc.creatorFlávia Lidiane Oliveira da Silva
dc.creatorLucas Antônio Miranda Ferreira
dc.creatorElaine Amaral Leite
dc.creatorGuilherme Carneiro
dc.date.accessioned2023-07-17T20:32:22Z
dc.date.accessioned2025-09-09T01:34:30Z
dc.date.available2023-07-17T20:32:22Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1590/s2175-97902018000417361
dc.identifier.issn2175-9790
dc.identifier.urihttps://hdl.handle.net/1843/56507
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso Aberto
dc.subjectMamas - Câncer
dc.subjectAgentes antineoplasicos
dc.subject.otherAll-trans-retinoic acid
dc.subject.otherBreast neoplasms
dc.subject.otherDrug delivery
dc.subject.otherHyaluronic acid
dc.subject.otherNanoemulsion
dc.titleHyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue4
local.citation.spage1
local.citation.volume54
local.description.resumoAll-trans retinoic acid (ATRA) has been studied for the treatment of cancer, including leukemia and breast cancer. This work aims to develop nanoemulsions (NE) loaded with a hydrophobic ion pair (HIP) of all-trans retinoic acid (ATRA) and a lipophilic amine, stearylamine (SA), and coated with hyaluronic acid (HA) to enhance anticancer activity and reducing toxicity. Blank NE was prepared by spontaneous emulsification and optimized prior to HIP incorporation. NE-ATRA was electrostatically coated with different concentrations of HA. Incorporation of ATRA-SA led to monodisperse NE with small size (129 ± 2 nm; IP 0.18 ± 0.005) and positive zeta potential (35.7 ± 1.0 mV). After coating with 0.5 mg/mL HA solution, the mean diameter slightly increased to 158 ± 5 nm and zeta potential became negative (-19.7 ± 1.2 mV). As expected, high encapsulation efficiency (near 100%) was obtained, confirmed by polarized light microscopy and infrared analysis. Formulations remained stable over 60 days and release of ATRA from NE was delayed after the hydrophilic HA-coating. HA-coated NE-ATRA was more cytotoxic than free ATRA for MDA-MB-231 and MCF-7 breast cancer cell lines, especially in the CD44 overexpressing cells. Blank coated formulations showed no cytotoxicity. These findings suggest that this easily-made HA-coated NE-ATRA formulation is a promising alternative for parenteral administration, thus improving the breast cancer therapy with this drug.
local.identifier.orcidhttps://orcid.org/0000-0003-2474-5536
local.identifier.orcidhttps://orcid.org/0000-0001-8812-3811
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.revistas.usp.br/bjps/article/view/159280

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