Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

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dc.creatorJôice Diascorrêa
dc.creatorAntônio Lúcio Teixeira
dc.creatorChiranjit Mukherjee
dc.creatorEugene j. Leys
dc.creatorTarcília Aparecida da Silva
dc.creatorDana t. Graves
dc.creatorGabriel r. Fernandes
dc.creatorDébora Cerqueira Calderaro
dc.creatorSantuza Maria Souza Mendonça
dc.creatorJanine Mayra Silva
dc.creatorMayra Laino Albiero
dc.creatorFernando q. Cunha
dc.creatore. Xiao
dc.creatorGilda Aparecida Ferreira
dc.date.accessioned2023-07-20T22:12:07Z
dc.date.accessioned2025-09-09T01:27:47Z
dc.date.available2023-07-20T22:12:07Z
dc.date.issued2019-06-10
dc.format.mimetypepdf
dc.identifier.doi10.1038/s41598-019-44674-6
dc.identifier.issn20452322
dc.identifier.urihttps://hdl.handle.net/1843/56823
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofscientific reports
dc.rightsAcesso Aberto
dc.subjectDisbiose
dc.subjectArtrite reumatóide
dc.subjectPeriodontite
dc.subjectCitocina
dc.subject.otherDysbiosis
dc.subject.otherArthritis, Rheumatoid
dc.subject.otherPeriodontitis
dc.subject.otherCytokine
dc.titleOral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue8379
local.citation.spage1
local.citation.volume9
local.description.resumoRheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-019-44674-6

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