Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma

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dc.creatorEloá Mangabeira Santos
dc.creatorCarlos Alberto de Carvalho Fraga
dc.creatorAlessandra Rejane Ericsson de Oliveira Xavier
dc.creatorMauro Aparecido de Souza Xavier
dc.creatorMarcela Gonçalves Souza
dc.creatorSabrina Ferreira de Jesus
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorLucyana Conceição Farias
dc.creatorSérgio Henrique Sousa Santos
dc.creatorTiago Góss dos Santos
dc.creatorFlávio Henrique Beraldo de Paiva
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2023-05-04T12:10:06Z
dc.date.accessioned2025-09-09T01:22:55Z
dc.date.available2023-05-04T12:10:06Z
dc.date.issued2021-04-25
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1111/jop.13188
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/52791
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology and Medicine
dc.rightsAcesso Restrito
dc.subjectCâncer
dc.subjectPríon - Doenças
dc.subjectMetástase
dc.subjectBioinformática
dc.titlePrion protein is associated with a worse prognosis of head and neck squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage994
local.citation.spage985
local.citation.volume50
local.description.resumoBackground: head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, and the biological changes with the activation of heat shock proteins (HSPs) and prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. This study investigates hypoxia's effect in lymph node metastasis by PRNP expression changes and its main partners. Methods: the study combined a theoretical/cell culture study with a case-control study. First, bioinformatics and cell culture were performed. A case-control study was performed in a second step by comparing HNSC patients with and without lymph node metastasis. Analyses: the Cancer Genome Atlas (TCGA) data source validates the theory in the global population study. Results: bioinformatics analysis suggests that hypoxia-inducible factor-1α (HIF1A) is associated with HSPA4, HSP90AA1 and PRNP expression. TCGA data validate the hypothesis that higher HSP90AA1, HSPA4 and PRNP are related to metastases and low survival. Herein, the cell study demonstrated that muted PRNP did not respond to hypoxia. Discussion: our results collectively provide the first evidence that PRNP promotes HNSC lymph node metastasis progression through the upregulation of HSPA4, HSP90AA1 and HIF1A. Our findings may provide a molecular basis for the promoting Role of PRNP in HNSC progression.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1111/jop.13188

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