Anonna crassiflora suppresses colonic carcinogenesis through its antioxidant effects, bioactive amines, and phenol content in rats

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dc.creatorPatrícia Felix Ávila
dc.creatorAngélica Pereira Todescato
dc.creatorMylena de Melo Carolo dos Santos
dc.creatorLuiz Fernando Ramos
dc.creatorIsabella Caroline Menon
dc.creatorMichele Oliveira Carvalho
dc.creatorMaysa do Vale Oliveira
dc.creatorFlávia Beatriz Custódio
dc.creatorMaria Beatriz Abreu Glória
dc.creatorBruno Martins Dala-Paula
dc.creatorPollyanna Francielli de Oliveira
dc.date.accessioned2025-09-05T22:48:24Z
dc.date.accessioned2025-09-08T23:20:55Z
dc.date.available2025-09-05T22:48:24Z
dc.date.issued2024-01
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.foodres.2023.113666
dc.identifier.issn09639969
dc.identifier.urihttps://hdl.handle.net/1843/84972
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectMarolo
dc.subjectAnonna crassiflora
dc.subjectCerrado brasileiro
dc.subject.otherMarolo
dc.subject.otherAtividade antioxidante
dc.subject.otherEspermina
dc.subject.otherFocos de criptas aberrantes
dc.subject.otherQuimioprevenção
dc.titleAnonna crassiflora suppresses colonic carcinogenesis through its antioxidant effects, bioactive amines, and phenol content in rats
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage1
local.citation.volume175
local.description.resumoMarolo (Annona crassiflora) is an underutilized Brazilian Cerrado fruit with few reports in the literature about its bioactive compounds and functional properties. In this context, the chemoprevention against the carcinogen 1,2-dimethylhydrazine (DMH)-induced pre-neoplastic lesions in Wistar rat colon was investigated and correlated with marolo’s antioxidant activity and the contents of phenolic compounds and bioactive amines. Total phenolic compounds (TPC) and total flavonoids compounds (TFC) were determined in the marolo pulp extract by spectrophotometric and Ultra-Performance Liquid Chromatography and diode array detection (UPLC-DAD) analysis. Free bioactive amines were determined by High Performance Liquid Chromatography and fluorescence detection (HPLC-FLD) after post column derivatization with o-phthalaldehyde. In addition, the in vitro antioxidant activity was determined by DPPH, and ABTS. Wistar rats were treated orally with marolo pulp at 0.7, 1.4 and 2.8 g/kg body weight (bw)/day added to a standard ration. Four subcutaneous injections of DMH (40 mg/kg bw) were used to induce a pre-neoplastic lesion that was assessed by the aberrant crypt foci (ACF) assay. The marolo pulp (fresh weigh) showed high content of total phenolic compounds (9.16 mg GAE/g), with predominance of chlorogenic acid (1.86 µg/g) and epicatechin (0.99 µg/g), and total flavonoids (7.26 mg CE/g), ∼85 % of the TPC. The marolo pulp had significant contents of tyramine (31.97 mg/kg), putrescine (20.65 mg/kg), and spermidine (6.32 mg/kg). The marolo pulp inhibited (p < 0.05) pre-neoplastic lesions induced by DMH administration at the all concentrations tested. These findings indicate that marolo pulp has a colon carcinogenesis chemopreventive effect, which could be due to, at least in parts, its antioxidant action associated with its phenolics and flavonoids content as well of spermidine.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0963996923012140

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