Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population

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dc.creatorGabriela Silveira-Nunes
dc.creatorAndrea Teixeira-Carvalho
dc.creatorClaudio Franceschi
dc.creatorSimone Rampelli
dc.creatorSilvia Turroni
dc.creatorPatrizia Brigidi
dc.creatorAna Maria Caetano Faria
dc.creatorDanielle Fernandes Durso
dc.creatorLuiz Roberto Alves de Oliveira Jr.
dc.creatorEloisa Helena Medeiros Cunha
dc.creatorTatiani Uceli Maioli
dc.creatorAngelica Thomaz Vieira
dc.creatorElaine Speziali
dc.creatorRodrigo Corrêa-oliveira
dc.creatorOlindo Assis Martins-filho
dc.date.accessioned2024-03-20T20:12:57Z
dc.date.accessioned2025-09-09T01:19:07Z
dc.date.available2024-03-20T20:12:57Z
dc.date.issued2020-03-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fphar.2020.00258
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/1843/66223
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Pharmacology
dc.rightsAcesso Aberto
dc.subjectMicrobiota
dc.subjectInflamação
dc.subjectHipertensão
dc.subjectImunidade
dc.subject.otherGut microbiota
dc.subject.otherDysbiosis
dc.subject.otherHypertension
dc.subject.otherInflammation
dc.subject.otherImmune profile
dc.titleHypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population
dc.typeArtigo de periódico
local.citation.epage14
local.citation.spage258
local.citation.volume11
local.description.resumoHypertension is a major global health challenge, as it represents the main risk factor for stroke and cardiovascular disease. It is a multifactorial clinical condition characterized by high and sustained levels of blood pressure, likely resulting from a complex interplay of endogenous and environmental factors. The gut microbiota has been strongly supposed to be involved but its role in hypertension is still poorly understood. In an attempt to fill this gap, here we characterized the microbial composition of fecal samples from 48 hypertensive and 32 normotensive Brazilian individuals by next-generation sequencing of the 16S rRNA gene. In addition, the cytokine production of peripheral blood samples was investigated to build an immunological profile of these individuals. We identified a dysbiosis of the intestinal microbiota in hypertensive subjects, featured by reduced biodiversity and distinct bacterial signatures compared with the normotensive counterpart. Along with a reduction in Bacteroidetes members, hypertensive individuals were indeed mainly characterized by increased proportions of Lactobacillus and Akkermansia while decreased relative abundances of well-known butyrate-producing commensals, including Roseburia and Faecalibacterium within the Lachnospiraceae and Ruminococcaceae families. We also observed an inflamed immune profile in hypertensive individuals with an increase in TNF/IFN-γ ratio, and in TNF and IL-6 production when compared to normotensive ones. Our work provides the first evidence of association of hypertension with altered gut microbiota and inflammation in a Brazilian population. While lending support to the existence of potential microbial signatures of hypertension, likely to be robust to age and geography, our findings point to largely neglected bacteria as potential contributors to intestinal homeostasis loss and emphasize the high vulnerability of hypertensive individuals to inflammation-related disorders.
local.identifier.orcidhttps://orcid.org/0000-0002-7538-3208
local.publisher.countryBrasil
local.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃO
local.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEM
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00258/full

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