Potential role of vacuumassisted procedures in resecting breast cancers and highlighting selection criteria to support future trials

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dc.creatorCarolina Nazareth Valadares
dc.creatorHenrique Lima Couto
dc.creatorAleida Nazareth Soares
dc.creatorPaola Hartung Toppa
dc.creatorBernardo Ricardo
dc.creatorStuart Mcintosh
dc.creatorNisha Sharma
dc.creatorVivian Resende
dc.date.accessioned2025-02-06T00:44:41Z
dc.date.accessioned2025-09-08T22:55:58Z
dc.date.available2025-02-06T00:44:41Z
dc.date.issued2023-09-21
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fonc.2023.1239574
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/1843/79690
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Oncology
dc.rightsAcesso Aberto
dc.subjectCâncer
dc.subjectBiopsia
dc.subjectProcedimentos minimamente invasivos
dc.subject.otherVacuum assisted biopsy
dc.subject.otherBreast cancer
dc.subject.otherMinimally invasive procedure
dc.subject.otherBreast
dc.subject.otherBiopsy
dc.titlePotential role of vacuumassisted procedures in resecting breast cancers and highlighting selection criteria to support future trials
dc.typeArtigo de periódico
local.citation.epage10
local.citation.spage01
local.citation.volume13
local.description.resumoPurpose: The purpose of this study was to evaluate the role of vacuum-assisted biopsy (VAB) in resecting breast cancers. Methods: Retrospective database analysis of 116 cancers [both invasive breast cancers (IC) and ductal carcinoma in situ (DCIS)] diagnosed by VAB submitted to standard surgical treatment with complete histological data from VAB and surgery. Excision following VAB was defined as complete resection (CR) if there was no residual tumor in the surgical specimen, minimal residual disease (MRD) if residual tumor ≤ 3 mm, gross residual disease (GRD) if residual tumor > 3 mm, and upgrade from DCIS on VAB to IC. CR and MRD were combined as potentially resected percutaneously (PRP). GRD and those with upgrade to IC were determined not eligible for percutaneous resection (NPR). Factors predictive of PRP were evaluated. Results: Mean age was 55.6 years (20–91; SD: 12,27). CR was seen in 29 of 116 cases (25%), MRD in 18 of 116 cases (15.5%), GRD in 64 of 116 cases (55.2%), and five of 116 cases (4.3%) were upgraded from DCIS to IC, and those groups combined represented 47 cases of PRP (40.5%) and 69 (59,5%) of NPR. For 77 tumors ≤ 10 mm, 45 (58.5%) were PRP. Multivariate analysis reveals significance for enlarged VAB (EVAB) (p = 0.008, OR: 4.4, 95% CI), low/intermediate nuclear grade (p < 0.001, OR: 12.5, 95% CI) and final tumor size (T) ≤ 10 mm (p = 0.001, OR: 50.1, 95% CI) for PRP. Conclusions: This study showed that lesions completely excised with VAB that were cancer could have been treated with VAB rather than surgery but tumor selection in terms of subtype and size is important.
local.identifier.orcidhttps://orcid.org/0000-0002-3513-6763
local.identifier.orcidhttps://orcid.org/0000-0002-3789-4461
local.identifier.orcidhttps://orcid.org/0000-0002-2671-3661
local.identifier.orcidhttps://orcid.org/0000-0001-6085-3644
local.identifier.orcidhttps://orcid.org/0000-0002-1891-1457
local.identifier.orcidhttps://orcid.org/0000-0002-4123-9611
local.identifier.orcidhttps://orcid.org/0000-0003-3991-0768
local.identifier.orcidhttps://orcid.org/0000-0003-4400-0427
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1239574/full

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