Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research

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dc.creatorLara Lopes
dc.creatorXiangjiang Guo
dc.creatorBogdan Yatsula
dc.creatorJianming Guo
dc.creatorYongquan gu
dc.creatorTúlio Pinho Navarro
dc.creatorAlan Dardik
dc.creatorOcean Setia
dc.creatorAfsha Aurshina
dc.creatorShirley Liu
dc.creatorHaidi hu
dc.creatorToshihiko Isaji
dc.creatorHaiyang Liu
dc.creatorTun Wang
dc.creatorShun Ono
dc.date.accessioned2023-07-17T21:48:34Z
dc.date.accessioned2025-09-09T00:26:54Z
dc.date.available2023-07-17T21:48:34Z
dc.date.issued2018
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s13287-018-0938-6
dc.identifier.issn1757-6512
dc.identifier.urihttps://hdl.handle.net/1843/56546
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofStem Cell Research Therapy
dc.rightsAcesso Aberto
dc.subjectAmputação
dc.subjectCicatrização
dc.subjectIsquemia Crônica Crítica de Membro
dc.subjectDiabetes Mellitus
dc.subject.otherStem cell therapy
dc.subject.otherCell therapy
dc.subject.otherDiabetic foot ulcer
dc.subject.otherDiabetic wound
dc.subject.otherCritical limb ischemia
dc.subject.otherWound healing
dc.subject.otherAmputation
dc.titleStem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue1
local.citation.spage188
local.citation.volume9
local.description.resumoBackground: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials.
local.identifier.orcidhttps://orcid.org/0000-0001-8134-5825
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0938-6

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