Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

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dc.creatorPaula Luize Camargos Fonseca
dc.creatorHelena P. Coelho
dc.creatorAlana V. B. Costa
dc.creatorWalyson C. Costa
dc.creatorAlex F. de Carvalho
dc.creatorBruna W. F. de Faria
dc.creatorAline Brito de Lima
dc.creatorEneida Santos de Oliveira
dc.creatorCarolina Senra Alves de Souza
dc.creatorFernanda Gil de Souza
dc.creatorRillery C. Dias
dc.creatorFilipe R. R. Moreira
dc.creatorVictor E. V. Geddes
dc.creatorIgor P. Godinho
dc.creatorAlessandro L. Gonçalves
dc.creatorKarine Lima Lourenço
dc.creatorRubens D. M. Magalhães
dc.creatorFrederico Scott Varella Malta
dc.creatorEva L. A. Medeiros
dc.creatorFernanda Santos Mendes
dc.creatorPedro H. B. de P. Mendes
dc.creatorCristiane P. T. B. Mendonça
dc.creatorRafael M. de Souza
dc.creatorAndre L. Menezes
dc.creatorDiego Menezes
dc.creatorMariane Talon de Menezes
dc.creatorLucyene Miguita Luiz
dc.creatorRennan G. Moreira
dc.creatorRenata B. Peixoto
dc.creatorDaniel Costa Queiroz
dc.creatorAdriana A. Ribeiro
dc.creatorAna Paula de B. Ribeiro
dc.creatorJuliana Wilke Saliba
dc.creatorNatalia Rocha Guimarães
dc.creatorHugo I. Sato
dc.creatorJoice do P. Silva
dc.creatorNatiely Pereira Silva
dc.creatorNuno R. Faria
dc.creatorSantuza Maria Ribeiro Teixeira
dc.creatorFlávio Guimarães da Fonseca
dc.creatorAna Paula Salles Moura Fernandes
dc.creatorDanielle Alves Gomes Zauli
dc.creatorJosé Nélio Januario
dc.creatorJaqueline Silva de Oliveira
dc.creatorNara de Oliveira Carvalho
dc.creatorFelipe Campos de Melo Iani
dc.creatorRenato Santana de Aguiar
dc.creatorRenan Pedra de Souza
dc.creatorTalita Émile Ribeiro Adelino
dc.creatorHugo José Alves
dc.creatorLuige Biciati Alvim
dc.creatorDarlan S. Candido
dc.date.accessioned2024-07-05T20:53:19Z
dc.date.accessioned2025-09-09T01:11:16Z
dc.date.available2024-07-05T20:53:19Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetos
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1093/ve/veac064
dc.identifier.issn2057-1577
dc.identifier.urihttps://hdl.handle.net/1843/69771
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVirus Evolution
dc.rightsAcesso Aberto
dc.subjectFilogenia
dc.subjectFilogeografia
dc.subjectVacinas contra COVID-19
dc.subjectVacinação
dc.subjectSARS-CoV-2
dc.titleTracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
dc.typeArtigo de periódico
local.citation.epage16
local.citation.issue2
local.citation.spage1
local.citation.volume8
local.description.resumoThe emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/ve/article/8/2/veac064/6650740?login=true

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