Clinicopathological and immunohistochemical features of the oral lymphoepithelial cyst: a multicenter study

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dc.creatorKarine Duarte da Silva
dc.creatorLuana Samara Balduino de Sena
dc.creatorPollianna Muniz Alves
dc.creatorTatiana Nayara Libório-'Kimura
dc.creatorBrendo Vinícius Rodrigues Louredo
dc.creatorJeconias Câmara
dc.creatorPatrícia Carlos Caldeira
dc.creatorLuiza Vale Coelho
dc.creatorAline Maria do Couto
dc.creatorMaria Cássia Ferreira de Aguiar
dc.creatorSandra Beatriz Chaves Tarquínio
dc.creatorAna Paula Neutzling Gomes
dc.creatorElismauro Francisco Mendonça
dc.creatorAline Carvalho Batista
dc.creatorCassiano Francisco Weege Nonaka
dc.date.accessioned2025-08-13T20:28:02Z
dc.date.accessioned2025-09-08T23:25:57Z
dc.date.available2025-08-13T20:28:02Z
dc.date.issued2020-03
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.12978
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/84364
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectCysts
dc.subjectImmunohistochemistry
dc.subjectLymphoid tissue
dc.subjectMouth
dc.subjectDemography
dc.subjectTongue
dc.subjectCarrier state
dc.subjectInflammation
dc.subjectHyperplasia
dc.subject.otherCysts
dc.subject.otherImmunohistochemistry
dc.subject.otherLymphoid tissue
dc.subject.otherMouth
dc.subject.otherNon-odontogenic cysts
dc.titleClinicopathological and immunohistochemical features of the oral lymphoepithelial cyst: a multicenter study
dc.typeArtigo de periódico
local.citation.epage226
local.citation.issue3
local.citation.spage219
local.citation.volume49
local.description.resumoBackground: Analyze the clinical, demographic, histopathological, and immunohistochemical features of oral lymphoepithelial cyst (OLEC). Methods: Samples were retrospectively retrieved from five oral pathology services. Clinical and demographic data were collected from patient charts. Histopathological and immunohistochemical (CD3 and CD20) features were evaluated. Data analysis involved descriptive statistics and bivariate analyses (P ≤ .05). Results: Seventy-seven cases were found among a total of 146 150 specimens (0.05%). OLEC was predominantly diagnosed in females (70.1%). Mean patient age was 46.51 years. The lesions arose mainly on the lateral border of the tongue (40.3%), measured up to 1 cm (61.0%), and were asymptomatic (64.9%). Twenty-four lesions (31.2%) were white. Forty-one cases (53.2%) presented lymphocytic inflammatory infiltrate with no specific arrangement. The cystic lining was composed of a non-keratinized stratified epithelium (59.7%) presenting hyperplasia (39.0%). Connection with the surface, epithelium was found in 23 cases (29.9%) and 31 (40.3%) cases had two or more cystic cavities. The lumen content was predominantly desquamated cells (48.1%). Subgemmal neurogenous plaque was found in 11/42 (26.2%) cases involving the tongue. CD20 cells predominated in 36/63 cases (57.2%), and lymphocytic inflammatory infiltrate was not always continuous around the cystic cavity (52.4%). + Conclusion: Lymphoepithelial cyst is an uncommon lesion of the oral cavity. The present study offers the largest sample of OLEC for which clinical, demographic, histopathological, and immunohistochemical features were evaluated. The clinical and demographic findings were similar to those described in previous reports, but the microscopic analyses revealed interesting aspects of the cystic epithelium and the lymphocytic inflammatory infiltrate in OLEC.
local.identifier.orcidhttps://orcid.org/0000-0003-2380-109X
local.identifier.orcidhttps://orcid.org/0000-0002-2117-5593
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0003-1496-4137
local.identifier.orcidhttps://orcid.org/0000-0001-5134-3466
local.identifier.orcidhttps://orcid.org/0000-0001-5007-5631
local.identifier.orcidhttps://orcid.org/0000-0002-9179-0145
local.identifier.orcidhttps://orcid.org/0000-0002-5057-4008
local.identifier.orcidhttps://orcid.org/0000-0001-7800-8326
local.identifier.orcidhttps://orcid.org/0000-0003-1297-4032
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12978

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