SUR1 receptor interaction with hesperidin and linarin predicts possible mechanisms of action of Valeriana officinalis in Parkinson

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dc.creatorGesivaldo Santos
dc.creatorLisandro Diego Giraldez-Alvarez
dc.creatorMarco Ávila-Rodriguez
dc.creatorFrancisco Capani
dc.creatorEduardo Galembeck
dc.creatorAristóteles Góes Neto
dc.creatorGeorge E. Barreto
dc.creatorBruno Andrade
dc.date.accessioned2023-06-15T21:26:53Z
dc.date.accessioned2025-09-08T23:50:16Z
dc.date.available2023-06-15T21:26:53Z
dc.date.issued2016
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fnagi.2016.00097
dc.identifier.issn1663-4365
dc.identifier.urihttps://hdl.handle.net/1843/54979
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Aging Neuroscience
dc.rightsAcesso Aberto
dc.subjectValeriana
dc.subjectDoença de Parkinson
dc.subjectNeuroproteção
dc.subjectReceptores de GABA-A
dc.subject.otherValeriana officinalis
dc.subject.otherParkinson disease
dc.subject.otherNeuroprotection
dc.subject.otherSUR1
dc.subject.otherGABAA
dc.titleSUR1 receptor interaction with hesperidin and linarin predicts possible mechanisms of action of Valeriana officinalis in Parkinson
dc.typeArtigo de periódico
local.citation.volume8
local.description.resumoParkinson’s disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested. In addiction to considering the PD as a result of mitochondrial metabolic imbalance and oxidative stress, such as in our previous in vitro model of rotenone, in the present manuscript we added a genomic approach to evaluate the possible underlying mechanisms of the effect of the plant extract. Microarray of substantia nigra (SN) genome obtained from Allen Brain Institute was analyzed using gene set enrichment analysis to build a network of hub genes implicated in PD. Proteins transcribed from hub genes and their ligands selected by search ensemble approach algorithm were subjected to molecular docking studies, as well as 20 ns Molecular Dynamics (MD) using a Molecular Mechanic Poison/Boltzman Surface Area (MMPBSA) protocol. Our results bring a new approach to Valeriana officinalis extract, and suggest that hesperidin, and probably linarin are able to relieve effects of oxidative stress during ATP depletion due to its ability to binding SUR1. In addition, the key role of valerenic acid and apigenin is possibly related to prevent cortical hyperexcitation by inducing neuronal cells from SN to release GABA on brain stem. Thus, under hyperexcitability, oxidative stress, asphyxia and/or ATP depletion, Valeriana officinalis may trigger different mechanisms to provide neuronal cell protection.
local.identifier.orcidhttps://orcid.org/0000-0001-8218-0292
local.identifier.orcidhttps://orcid.org/0000-0003-4612-3236
local.identifier.orcidhttps://orcid.org/0000-0003-0342-0628
local.identifier.orcidhttps://orcid.org/0000-0003-4238-5546
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.identifier.orcidhttps://orcid.org/0000-0002-6644-1971
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fnagi.2016.00097/full

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