Concentration-dependent effect of bleaching agents on the immunolabeling of interleukin-6, interleukin-17, and cd5-positive cells in the dental pulp

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dc.creatorFrancine Benetti
dc.creatorJoão Eduardo Gomes Filho
dc.creatorFerreira
dc.creatorGustavo Sivieri de Araújo
dc.creatorEdilson Ervolino
dc.creatorAndré Luiz Fraga Briso
dc.creatorLuciano Tavares Angelo Cintra
dc.date.accessioned2022-09-24T20:14:29Z
dc.date.accessioned2025-09-09T01:16:21Z
dc.date.available2022-09-24T20:14:29Z
dc.date.issued2018-01-20
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doi10.1111/iej.12891
dc.identifier.issn01432885
dc.identifier.urihttps://hdl.handle.net/1843/45481
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofInternational Endodontic Journal
dc.rightsAcesso Aberto
dc.subjectTooth bleaching
dc.subjectInterleukin-17
dc.subjectInterleukin-6
dc.subjectDental pulp cavity
dc.subjectHydrogen peroxide
dc.subject.otherCD5
dc.subject.otherDental pulp
dc.subject.otherHydrogen peroxide
dc.subject.otherInterleukin-17
dc.subject.otherInterleukin-6
dc.subject.otherTooth bleaching
dc.titleConcentration-dependent effect of bleaching agents on the immunolabeling of interleukin-6, interleukin-17, and cd5-positive cells in the dental pulp
dc.typeArtigo de periódico
local.citation.epage799
local.citation.issue07
local.citation.spage789
local.citation.volume51
local.description.resumoAim: To evaluate lymphocyte-like cell activation (CD5-positive cells) and the expression of interleukin (IL)-6 and IL-17 in the pulp after tooth bleaching with two concentrations of hydrogen peroxide (H2 O2 ). Methodology: The right and left maxillary molars from 40 rats were treated randomly with bleaching gel with 20% H2 O2 (BLUE group, 1 application of 50 min), 35% H2 O2 (MAXX group, three applications of 15 min), or placebo gel (control). After 2 and 30 days, the rats were killed (n = 10), and the jaws were processed for histological and immunohistochemistry analysis of the pulp tissue. The scores of inflammation and immunolabelling (IL-6/IL-17) were submitted to Mann-Whitney and Kruskal-Wallis followed Dunn tests, respectively; anova tests were used for comparisons of number of CD5-positive cells and pulp chamber area values (P < 0.05). Results: At 2 days, 60% of specimens of the BLUE group were associated with moderate inflammation in pulp horns, and in the MAXX group with necrosis (P < 0.05). At 30 days, the pulp was organized, and tertiary dentine was formed. The MAXX group had superior immunolabelling of IL-17 at 2 days differing significantly from other groups (P < 0.05). At 2 days, 90% of the specimens of the BLUE group had moderate immunolabelling of IL-6, and 50% of the MAXX group had severe immunolabelling, both significantly different from the control (P < 0.05). There was no significant difference between the groups at 30 days (P > 0.05). CD5-positive cells were present at 2 and 30 days, particularly in the bleached groups (P < 0.05), without significant difference between time periods (P > 0.05). Conclusions: IL-6 and IL-17 participated in inflammation in the pulp tissue of rats after tooth bleaching, particularly at 2 days. The immunolabelling was greater with increasing H2 O2 concentration. This process was accompanied by the prolonged activation of CD5-positive cells.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12891

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