The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis

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dc.creatorRafael de Pinhoqueiroz
dc.creatorDaniele Viana Inês
dc.creatorFelipe Telöken Diligenti
dc.creatorVictor Haygert Schnor
dc.creatorJacobo Melamed
dc.creatorWesley Ribeiro Campos
dc.creatorDaniel Vítor de Vasconcelos Santos
dc.date.accessioned2023-06-06T21:33:20Z
dc.date.accessioned2025-09-09T01:14:40Z
dc.date.available2023-06-06T21:33:20Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doi10.1186/s12348-019-0169-8
dc.identifier.issn18695760
dc.identifier.urihttps://hdl.handle.net/1843/54630
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Ophthalmic Inflammation and Infection
dc.rightsAcesso Aberto
dc.subjectEpidemiologia
dc.subjectPrognóstico
dc.subjectInfecções Sexualmente Transmissíveis
dc.subjectSífilis
dc.subjectUveíte
dc.subject.otherEpidemiology
dc.subject.otherPrognosis
dc.subject.otherSexually transmitted diseases
dc.subject.otherSyphilis
dc.subject.otherUveitis
dc.titleThe ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis
dc.typeArtigo de periódico
local.citation.epage6
local.citation.issue2
local.citation.spage1
local.citation.volume9
local.description.resumoBackground: Syphilitic uveitis is reemerging globally, may lead to any type of intraocular inflammation, and is potentially sight-threatening. We aim to characterize clinical features and prognostic factors in patients with syphilitic posterior uveitis. Methods: Retrospective chart review at two tertiary university-based referral centers in Brazil. Clinical data, laboratory results, and treatment outcomes were analyzed. Statistical analysis was performed using Fisher’s exact test for categorical variables and Mann-Whitney U test for continuous variables. Results: Forty-four patients (81 eyes) were consecutively diagnosed with syphilitic posterior uveitis between March 2011 and April 2013.Thirty-one were male (70.5%) and the mean age was 43.8 years (range 15–81). HIV confection was disclosed in 12 patients (29.3%). The most prevalent finding was vitritis (85.2%), followed by retinal involvement (76.4%) and optic disc abnormalities (63.5%). After treatment, mean visual acuity improved from 1.2 (20/320) to 0.6 (20/80; median 20/30), but 19 eyes (23.5%) persisted with ≤ 1.0 (20/200). Factors associated with final visual acuity ≤ 1.0 despite therapy were prior use of systemic corticosteroids (p = 0.001), higher Venereal Disease Research Laboratory titers (p = 0.004), longer duration of symptoms (p = 0.024), and worse initial VA (p < 0.001). Conclusions: Syphilitic uveitis is reemerging. Delayed diagnosis and inadvertent use of systemic corticosteroids are potentially modifiable prognostic factors to be considered for possibly improving outcomes.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://joii-journal.springeropen.com/articles/10.1186/s12348-019-0169-8

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