No change in brain-derived neurotrophic factor levels following a single session of light to-moderate intensity walk in chronic stroke patients
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Background: Many studies show the beneficial effects of overground gait training in stroke patients. However, it is not know whether it is able to induce changes in brain-derived neurotrophic factor (BDNF) levels, which could positively influence neurophysiological mechanisms. Objective: To evaluate the effect of a single session of light-to-moderate intensity walk on BDNF serum levels and its precursors (proBDNF) in chronic ischemic stroke patients. Methods: Patients were asked to walk for 30 minutes in the target heart rate training zone (30-60% of maximal heart rate). Blood samples were collected immediately before and after a single session. Results: Fifteen individuals with 60.8 (7.7) years old participated of this study. There was no significant difference in proBDNF (p=0.573) and BDNF (p=0.563) serum levels between pre- and post-session. Conclusion: This study used light-to-moderate intensity because the goal is to approach the gait training in clinical setting. The lack of increase in BDNF levels can be explained by two reasons: the intensity zone of the heart rate selected during the session and not having a gradual increase in this intensity.
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Acidente Vascular Cerebral, Fator Neurotrófico Derivado do Encéfalo, Exercício Físico, Pacientes
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https://www.hilarispublisher.com/abstract/no-change-in-brainderived-neurotrophic-factor-levels-following-a-single-session-of-light-tomoderate-intensity-walk-in-ch-37029.html