Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation

Página do item simplificado
dc.creatorViviane Lima Batista
dc.creatorÊnio Ferreira
dc.creatorJuliana Guimarães Laguna
dc.creatorLuiz Carlos Júnior Alcântara
dc.creatorVasco Ariston de Carvalho Azevedo
dc.creatorLuís Cláudio Lima de Jesus
dc.creatorLaísa Macedo Tavares
dc.creatorFernanda Alvarenga Lima Barroso
dc.creatorLucas Jorge da Silva Fernandes
dc.creatorAndria Dos Santos Freitas
dc.creatorMonique Ferrary Américo
dc.creatorMariana Martins Drumond
dc.creatorPamela Mancha-agresti
dc.date.accessioned2023-11-06T20:30:50Z
dc.date.accessioned2025-09-08T23:54:33Z
dc.date.available2023-11-06T20:30:50Z
dc.date.issued2022-07-14
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/microorganisms10071418
dc.identifier.issn2076-2607
dc.identifier.urihttps://hdl.handle.net/1843/60510
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMicroorganisms
dc.rightsAcesso Aberto
dc.subjectMicrobiologia
dc.subjectMucosite
dc.subjectTratamento Farmacológico
dc.subjectIntestinos
dc.subjectImunomodulação
dc.subject.otherMucositis
dc.subject.otherChemotherapy
dc.subject.otherIntestinal damage
dc.subject.otherHeat-killed bacteria
dc.subject.otherCell-free supernatant
dc.subject.otherImmunomodulation
dc.titleParaprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation
dc.typeArtigo de periódico
local.citation.epage18
local.citation.issue7
local.citation.spage1418
local.citation.volume10
local.description.resumoIntestinal mucositis is a commonly reported side effect in oncology practice. Probiotics are considered an excellent alternative therapeutic approach to this debilitating condition; however, there are safety questions regarding the viable consumption of probiotics in clinical practice due to the risks of systemic infections, especially in immune-compromised patients. The use of heat-killed or cell-free supernatants derived from probiotic strains has been evaluated to minimize these adverse effects. Thus, this work evaluated the anti-inflammatory properties of paraprobiotics (heat-killed) and postbiotics (cell-free supernatant) of the probiotic Lactobacillus delbrueckii CIDCA 133 strain in a mouse model of 5-Fluorouracil drug-induced mucositis. Administration of paraprobiotics and postbiotics reduced the neutrophil cells infiltrating into the small intestinal mucosa and ameliorated the intestinal epithelium architecture damaged by 5-FU. These ameliorative effects were associated with a downregulation of inflammatory markers (Tlr2, Nfkb1, Il12, Il17a, Il1b, Tnf), and upregulation of immunoregulatory Il10 cytokine and the epithelial barrier markers Ocln, Cldn1, 2, 5, Hp and Muc2. Thus, heat-killed L. delbrueckii CIDCA 133 and supernatants derived from this strain were shown to be effective in reducing 5-FU-induced inflammatory damage, demonstrating them to be an alternative approach to the problems arising from the use of live beneficial microorganisms in clinical practice.
local.identifier.orcidhttps://orcid.org/0000-0002-1835-0303
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2076-2607/10/7/1418

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Paraprobiotics and Postbiotics of Lactobacillus delbrueckii CIDCA 133 Mitigate 5-FU-Induced Intestinal Inflammation.pdf
Tamanho:
1.43 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG