Bactérias multirresistentes: Klebsiella pneumoniae carbapenemase enzima KPC nas Infecções Relacionadas à Assistência à Saúde (IRAS)

Abstract

The Associated Infections at Health Care (AIHC) can be classified as those acquired by the people while they are receiving treatment for another condition in a health care environment. When reported, these infections are characterized as the most obvious symptoms of the inadequacy of the health system. The environment occupied by colonized or infected patients may become contaminated by bacteria and constitute a secondary reservoir, which favors cross transmission. Thus, there is the appearance of new strains that produce enzymes -lactamases such as the type of broad spectrum (ESBL), AmpC carbapenemases and, among them, metallo-beta-lactamases and KPC, which are capable of degrading antibiotics, and may also produce changes that prevent the entry or change the site of action of drugs that are part of the resistance mechanisms of Gram-negative bacteria. The isolation of these bacteria and the explanation of their resistance mechanisms further knowledge about the performance of multiresistant bacteria, helping the industries to seek new antimicrobial, drugs able to reduce infections difficult to treat. Strategies that favor the fight against multidrug-resistant bacteria have not only on the control of drugs based on antimicrobial, alone or in association substances, ranking them in the use of prescription, but also on the need to strengthen the maintenance of appropriate conditions hygiene action as extremely important in the prevention and control of HAIC.